血清TSH、TGAb、TPOAb联合超声特征对良恶性甲状腺结节的诊断价值

Diagnostic value of serum TSH, TGAb, TPOAb combing Ultrasound features in Benign malignant thyroid nodules

目的探讨血清TSH、TGAb、TPOAb联合超声特征对甲状腺结节良恶性的诊断价值。方法选取2013年1月~2015年12月的189例甲状腺结节纳入观察,良性100例,恶性89例。对良、恶性组间超声特征及血清学指标进行对照分析。结果实性、形态不规则、边界不清、低回声、纵横比>1及微钙化等超声特征在良、恶性组间差异有统计学意义。良、恶性组间TGAb、TPOAb阳性率差异有统计学意义,TSH水平则无显著差异。平行试验显示,甲状腺结节出现3个超声特征和TPOAb阳性或TGAb阳性时,特异性最高(93.0%);序列试验显示,甲状腺结节出现3个超声特征和TGAb、TPOAb均阳性时,特异性高达100%。结论超声检查结合血清TGAb、TPOAb检测在甲状腺结节良恶性鉴别中具有重要应用价值,可在临床借鉴应用。

Objective To investigate the diagnostic value of serum TSH,TGAb,TPOAb combing ultrasound features in benign malignant thyroid nodules.Methods One hundred and eighty-nine cases of thyroid nodule patients from January 2013 to December 2015 including benign 100 cases and malignancy 89 cases were selected.The ultrasound features and serum indexes were compared between benign and malignancy.Results There were significant differences between the benign and malignant groups in the ultrasonic characteristics of the ultrasonic solid,irregular shape,obscure boundary,hypoecho,aspect ratio>1 and micro-calcification.The positive incidence of TGAb and TPOAb had a significant difference between benign and malignancy(P<0.05).TSH in two group had no significant difference(P>0.05).After parallel test,when thyroid nodule had three ultrasound features and TPOAb positive or TGAb positive,the specificity was 93.0%.After sequential test,when thyroid nodule had three ultrasound features and TPOAb positive and TGAb positive,the specificity was 100%.Conclusion Ultrasonic examination combing serum TGAb,TPOAb detection have a great application value on distinguishing the benign and malignant of thyroid nodule.It can be used for reference in clinical practice.