地西泮联合心理干预治疗男性酒精依赖伴抑郁症的临床疗效观察

Clinical effects of Diazepam combined with psychological intervention in treatment of male patients with alcohol dependence and depression

目的:分析地西泮联合心理干预治疗酒精依赖伴抑郁症的临床疗效。方法:选取114例酒精依赖伴抑郁症的患者作为研究对象。按照入院编号进行分组,单号为对照组,双号为观察组,各57例。对照组采用口服地西泮进行治疗,观察组在对照组基础上联合心理干预进行治疗。对比分析两组治疗前及治疗后汉密尔顿抑郁量表(HAMD-17)评分及戒断症状量表评分,简易智力状况检查法(MMSE)评分及临床疗效。结果:(1)观察组总有效率91.2%,明显高于对照组的77.2%(P<0.05)。(2)患者治疗后2周、4周、6周、8周时,观察组HAMD量表评分分别为(22.83±3.82)分、(16.73±3.42)分、(13.26±3.58)分、(10.23±4.38)分,明显高于对照组的(26.71±4.02)分、(19.63±4.52)分、(16.52±3.43)分、(13.72±3.84)分(P<0.05);(3)患者治疗后1周、2周、3周、4周时观察组的戒断症状评分显著优于对照组(P均<0.05)。(4)观察组治疗前MMSE评分为(12.64±4.30)分,明显高于治疗后的(26.23±3.26)分(P<0.05);对照组治疗前为(12.24±4.58)分,明显高于治疗后的(22.09±4.38)分(P<0.05);观察组治疗后的MMSE评分为(26.23±3.26)分,明显高于对照组的(22.09±4.38)分(P<0.05)。结论:地西泮联合心理干预治疗酒精依赖伴抑郁症优于采用地西泮治疗,在改善患者的情绪、认知功能方面效果显著。

Objective:To analyze clinical effects of Diazepam combined with psychological intervention in treatment of alcohol dependence and depression.Methods:114 patients with alcohol dependence and depression were selected as the study subjects.According to the admission number,those with odd number were set as control group,while those with even numbers were selected as observation group,57 cases in each.The control group was treated with oral Diazepam,while the observation group was treated with psychological intervention on the basis of that of the control group.The scores of Hamilton depression scale(HAMD-17)and withdrawal symptoms scale before and after the treatment in the two groups were compared,and the MMSE scorea and clinical effects were compared.Results:(1)The total effective rate of the observation group was 91.2%,which was significantly higher than that of the control group(77.2%)(P<0.05).(2)2,4,6 and 8 weeks after the treatment,the scores of the HAMD in the observation group were(22.83±3.82)points,(16.73±3.42)points,(13.26±3.58)points,(10.23±4.38)points,which were significantly higher than(26.71±4.02)points,(19.63±4.52)points,(16.52±3.43)points,(13.72±3.84)points in the control group(P<0.05).(3)1,2,3 and 4 weeks after the treatment,the withdrawal symptoms scores of the observation group were significantly better than those of the control group(P<0.05).(4)The MMSE score in the observation group before the treatment(12.64±4.30)was significantly lower than that after the treatment(6.23±3.26)(P<0.05);the MMSE score in the control group before the treatment(12.24±4.58)was significantly lower than that after the treatment(22.09±4.38)(P<0.05);and the MMSE score in the observation group was significantly better than that in the control group after the treatment(P<0.05).Conclusions:Diazepam combined with psychological intervention in the treatment of the patients with alcohol dependence and depression is more effective than single Diazepam.Moreover,it can improve the patients'emotional and cognitive function significantly.