巩固维持期精神分裂症患者血脂异常的影响因素

Influence factors of dyslipidemia in patients with schizophrenia at consolidation and maintenance phase

目的:探讨巩固维持期精神分裂症患者血脂异常的影响因素。方法:采用横断面研究的方法,对79名精神分裂症巩固维持期治疗患者,采用多元线性回归的方法从人口学资料、症状学、治疗药物三个方面寻找与血脂异常相关的因素。结果:患者的教育水平(β=-0.572,P=0.039)与TG水平显著相关,而性别(β=0.475,P=0.013)和PANSS总分(β=-0.27,P=0.024)则与HDL-c的水平显著相关。结论:患者的受教育水平、性别和巩固维持期精神分裂症的残留症状为巩固维持期精神分裂症患者血脂异常的影响因素。

Objective:To explore influence factors of dyslipidemia in schizophrenia patients at consolidation and maintenance phase.Methods:In this cross-sectional study,79 patients with schizophrenia at consolidation and maintenance phase were studied.Multiple linear regression was used to find out the factors related to dyslipidemia from demographic data,symptomatology,and therapeutic drugs.Results:The level of education(β=-0.572,P=0.039)was significantly associated with TG levels,while gender(β=0.475,P=0.013)and PANSS scores(β=-0.27,P=0.024)were obviously associated with HDL-c levels.Conclusions:The level of education,gender,and the residual symptoms of the schizophrenia patients at consolidation and maintenance phase are the influence factors of their dyslipidemia.