神经内窥镜在高血压脑出血治疗中的应用及对血清SF MBP GFAP的影响

Application of Neuroendoscopy in the Treatment of Hypertensive Intracerebral Hemorrhage and its Effects on Serum SF MBP and GFAP

目的:研究神经内窥镜在高血压脑出血治疗中的应用及对血清铁蛋白(SF)、髓鞘碱性蛋白(MBP)、胶质纤维酸性蛋白(GFAP)的影响。方法:选取2014年8月至2015年7月我院收治的78例高血压脑出血患者,根据随机数字法分为观察组和对照组,每组39例。观察组使用神经内窥镜完成治疗,对照组采取大骨瓣开颅术完成治疗。比较两组患者临床疗效,术中术后情况,血清SF、MBP、GFAP水平。结果:疗后,观察组临床总有效率显著高于对照组(P<0.05)。观察组皮肤切口长度、皮层切口长度、骨窗大小、手术时间、失血量显著小于对照组(P<0.05)。两组患者血肿清除率、再出血率、颅内感染率、死亡率比较无显著差异(P>0.05)。两组患者术前血清SF、MBP、GFAP水平比较无显著差异(P>0.05),术后,两组患者血清SF、MBP、GFAP水平显著低于术前(P<0.05),观察组显著低于对照组(P<0.05)。结论:神经内窥镜在治疗高血压脑出血中,能有效降低患者血清SF、MBP、GFAP水平,缩短患者皮肤切口长度、皮层切口长度、手术时间,降低失血量,临床疗效良好,有利于患者预后。

Objective:To study the application of neuroendoscopy on hypertensive intracerebral hemorrhage and its effects on serum ferritin(SF),myelin basic protein(MBP)and glial fibrillary acidic protein(GFAP).Methods:78 patients with hypertensive intracerebral hemorrhage admitted to our hospital from August 2014 to July 2015 were randomly divided into observation group and control group,39 cases in each group.The observation group completed the treatment with neuroendoscopy,and the control group were taken the big bone flap craniotomy to complete the treatment.The clinical curative effect,intraoperative and postoperative situation,serum SF,MBP and GFAP levels were compared between the two groups.Results:After treatment,the total effective rate in the observation group was significantly higher than that in the control group(P<0.05).The skin incision length,cortical incision length,bone window size,operation time and blood loss in observation group were significantly less than those in control group(P<0.05).There was no significant difference in hematoma clearance rate,rebleeding rate,intracranial infection rate and mortality between the two groups(P>0.05).Before operation,there was no significant difference in serum SF,MBP and GFAP between the two groups(P>0.05).After operation,serum SF,MBP and GFAP levels in both groups were significantly lower than those before operation(P<0.05),observation group were lower than the control group(P<0.05).Conclusion:Neuroendoscopy in the treatment of hypertensive intracerebral hemorrhage,can effectively reduce the serum levels of SF,MBP,GFAP,shorten the skin incision length,cortical incision length,operation time,reduce blood loss,clinical efficacy is good,is conducive to the prognosis of patients.