丹红注射液联合缬沙坦对慢性肾衰竭患者的疗效及相关因子的影响

Effect of Danhong Injection combined with Valsartan on Efficacy and Related Factors in Patients with Chronic Renal Failure

目的:研究丹红注射液联合缬沙坦对慢性肾衰竭患者的疗效及相关因子的影响。方法:收集2015年3月至2016年3月我院收治的慢性肾衰竭患者90例,随机分为对照组和治疗组,各45例。两组患者均采用常规治疗,并给予缬沙坦口服,80mg/次,1次/d。治疗组在对照组的基础上,采用丹红注射液治疗,每次40m L,加入5%葡萄糖注射液200m L中,静脉滴注,1次/d。两组治疗疗程均为一个月。分析两组患者疗效、临床症状积分、肾功能指标(24h尿白蛋白、血尿素氮、血肌酐)水平,检测血清TGF-β1、VEGF、MCP-1、ANGⅡ水平。结果:治疗组总有效率显著高于对照组(P<0.05);倦怠乏力、腰膝酸软、食少纳呆、夜尿清长积分均显著低于对照组(P<0.05);UAE、SCr水平显著低于对照组(P<0.05),BUN水平显著高于对照组(P<0.05);血清TGF-β1、VEGF、MCP-1、ANGⅡ水平均显著低于对照组(P<0.05)。结论:丹红注射液联合缬沙坦治疗慢性肾衰竭疗效显著,能够改善患者的临床症状、降低尿蛋白、改善肾脏微循环,保护肾功能,可显著降低血清TGF-β1、VEGF、MCP-1、ANGⅡ水平,缓解病情发展。

Objective:To study the effect of Danhong injection combined with valsartan on chronic renal failure and its related factors.Methods:90 patients of chronic renal failure received therapy from March 2015 to March 2016 in our hospital were selected as research objects.According to the draw method divided into control group(n=45)and treatment group(n=45).Two groups of patients were treated with conventional treatment.The control group was treated with valsartan,80mg per day,once a day.While the treatment group,on the basis of control group,treated with Danhong injection,40mg per day,Add 5%glucose injection 200mL and mix intravenously,once a day.The two groups were treated for one month.Then treatment effect,clinical symptom score,renal function index,the level of 24 h urinary albumin(UAE),blood urea nitrogen(BUN),serum creatinine(SCr),the serum level of TGF-1,beta 1,VEGF,MCP-1,ANG II of two groups were compared.Results:The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05);Lassitude,anorexia,clear night urine scores were significantly lower than the control group(P<0.05);The levels of UAE,BUN and Cr were significantly lower than those of the control group(P<0.05);The levels of TGF-1,beta 1,VEGF,MCP-1 and ANG II were significantly lower than those of the control group(P<0.05).Conclusion:Danhong injection combined with valsartan is well for chronic renal failure,which can improve the clinical symptoms,reduce urinary protein,improve the microcirculation of the kidney,and protect the renal function.It can significantly reduce the levels of serum TGF-β1,VEGF,MCP-1,ANG II,and alleviate the development of the disease.