血浆NT-proBNP对心肌梗死发病部位及与预后的关系分析

The Relationship between Plasma NT-proBNP and the Prognosis on Location Myocardial Infarction

目的:分析血浆氨基末端脑钠肽前体(NT-proBNP)对心肌梗死发病部位及与预后的关系分析。方法:选择我院2017年1月至2017年12月收治的120例心肌梗死患者,均以酶联免疫法检测血浆NT-proBNP水平。分析血浆NT-proBNP和不同发病部位、Gensini积分、心血管事件和预后的联系。结果:前壁梗死组NT-proBNP水平依次高于前侧壁梗死组、前间壁梗死组及下壁梗死组,比较有统计学差异(P<0.05)。重度组NT-proBNP高于中度组且高于轻度组,比较有统计学差异(P<0.05)。发生心肌梗死再发、心力衰竭及心源性死亡组血浆NT-proBNP水平均分别高于未发生组(P<0.05)。多因素Logistic回归可见,前壁梗死、Gensini积分、NT-proBNP为心肌梗死患者预后影响的独立危险因素。NT-proBNP水平ROC曲线下面积为0.649(95%cl为0.508~0.790,P<0.001),cutoff值为0.162,敏感度及特异度分别为0.561和0.731。结论:血浆NT-proBNP能够反映心肌梗死的发病部位,且可作为预测患者预后的重要生物标志物,值得临床推广。

Objective:To analyze the effect of amino-terminal pro-brain natriuretic peptide(NT-proBNP)on the disease site of myocardial infarction and prognosis.Methods:120 patients with myocardial infarction received therapy from January 2017 to June 2017,plasma NT-proBNP levels were detected by enzyme-linked immunoassay.The relationship between the plasma NT-proBNP and the different sites,Gensini integrals,cardiovascular events and prognosis was analyzed.Results:Level of NT-proBNP in the anterior wall infarction group was higher than that of the anterior wall infarction group,the anterior wall infarction group and the lower wall infarction group,there was a statistical difference(P<0.05).NT-proBNP in severe group was higher than the moderate group and was higher than the mild group,with a statistically significant difference(P<0.05).The plasma NT-proBNP level in recurrent myocardial infarction,heart failure and cardiac death group was higher than that in the untreated group(P<0.05).Multivariate Logistic regression showed that the anterior wall infarction,Gensini integral and NT-proBNP were independent risk factors for the prognosis of myocardial infarction patients.The area under the ROC curve of the NT-proBNP level was 0.649(95%cl was 0.508~0.790,P<0.001),the cutoff value was 0.162,and the sensitivity and specificity were 0.561 and 0.731.Conclusion:NT-proBNP can reflect the location of myocardial infarction,and can serve as an important biomarker for predicting the prognosis of patients.