缬沙坦联合益肾化湿颗粒对慢性肾小球肾炎患者肾功能的影响及安全性

Effect of valsartan combined with Yishen Huashi granules on renal function in patients with chronic glomerulonephritis and its safety

目的 探讨缬沙坦联合益肾化湿颗粒对慢性肾小球肾炎患者肾功能的影响及安全性。方法选取2015年1月至2017年6月在本院就诊的慢性肾小球肾炎患者90例,采用数字随机方法分为对照组和研究组,各45例。对照组予以西医常规治疗(缬沙坦胶囊,连续用药8周),研究组予西医常规治疗加益肾化湿颗粒,均连续治疗8周。观察患者总疗效及实验室检查(Scr、BUN、ALB、24 h尿蛋白定量),判定治疗前后患者的腰脊酸软、浮肿、疲倦乏力症状程度,观察两组患者治疗期间不良反应情况。结果治疗后,两组患者Scr、BUN、24 h尿蛋白水平显著降低,ALB水平显著升高,且研究组Scr、BUN、24 h尿蛋白水平显著低于对照组,ALB水平显著高于对照组,差异有统计学意义(P<0.05);研究组总有效率91.11%,高于对照组总有效率62.22%,中医证候评分显著低于对照组,差异有统计学意义(P<0.05)。研究组不良反应率为6.67%,对照组不良反应率为11.11%,两组患者不良反应比较,差异无统计学意义(P>0.05)。结论 益肾化湿颗粒联合缬沙坦治疗慢性肾炎,能够显著改善患者的肾功能,改善中医证候,且具有较好的安全性。

Objective To investigate the effect of valsartan combined with Yishen Huashi granules on renal function in patients with chronic glomerulonephritis and its safety.Methods The selected cases were randomly divided into a control group and a study group in average.The control group were treated with conventional western medicine(calsartan capsules)for 8 weeks,and the study group with conventional western medicine and Yishen Huashi granules for 8 weeks.The total curative effect and the Scr,BUN,ALB,24 h urinary protein quantitative determination were observed.Before and after the treatment,the lumbar debility,edema,and fatigue degree were judged.The adverse reactions during the treatment were observed.Results The levels of Scr,BUN,and 24 h urinary protein were significantly lower and the level of ALB was significantly higher after than before the treatment in both groups and were so in the study group than in the control group after the treatment,with statistical differences(all P<0.05).The total effective rate was 91.11%in the study group,and was 62.22%the control group(P<0.05).The score of TCM syndromes was significantly lower in the study group than in the control group(P<0.05).The incidence of adverse reactions was 6.67%in the study group,and was 11.11%in the control group(P>0.05).Conclusion Yishen Huashi granules combined with valsartan in the treatment of chronic glomerulonephritis can significantly improve the patients’renal function and TCM syndromes and is safe.