高迁移率族蛋白-1在药物性肝损伤中的研究进展

Research progress on high mobility group protein box 1 in drug induced liver injury

高迁移率族蛋白-1(high mobility group protein box 1,HMGB1)是一个广泛存在于各种真核细胞的核非组蛋白,其结合在染色体上,可保证染色体结构的稳定。HMGB1也可因细胞炎症或坏死释放到细胞外,此时其可介导激活自身免疫应答(包括炎症趋化和细胞因子的释放)。近年来关于HMGB1在药物性肝损伤致病机制和临床价值方面的作用也越来越引起重视。本文就HMGB1在药物性肝损伤中的作用机制以及在动物模型和临床研究中的进展进行综述。

High mobility group protein box 1(HMGB1)is a ubiquitous nuclear non-histone protein binding on the chromosome to ensure the stability of its structure in almost all eukaryotic cells.However,HMGB1 can be extracellularly released because of cell inflammation or necrosis,where it mediates activation of innate immune responses,including chemotaxis and cytokine release.In recent years,more and more attention has been paid to the role of HMGB1 in the mechanism and clinical value of drug-induced liver injury.This article reviews the mechanism of HMGB1 in the drug induced liver injury,as well as some progress in animal models and clinical studies.