Krüppel样因子4在成牙本质细胞分化及口腔鳞状细胞癌中作用的研究进展

Research Progress on the Role of Krüppel-like Factors 4in Odontoblast Differentiation and Oral Squamous Cell Carcinoma

Krüppel样因子4(Krüppel-like factors 4,KLF4)是一种在全身多处表达的锌指转录因子,参与调控细胞增殖、分化、胚胎发育及肿瘤发生等众多重要生理病理过程,其在口腔中也有特异性表达。本文从KLF4的结构、生物学功能、在成牙本质细胞分化中的作用及其在口腔鳞状细胞癌中的作用等方面的研究进展作一综述。

Krüppel-like factors 4(KLF4),a member of the KLF family,is a zinc-finger transcription factor.KLF4 is involved in the regulation of proliferation,differentiation,apoptosis,somatic cell reprogramming,tumorigenesis,and many other important physiologic processes.The expression of KLF4 in the oral tissue is biochemically and functionally significant.This paper investigated the biochemical activities of KLF4,and the function of KLF4 in odontoblast differentiation and oral squamous cell carcinoma.