原发性高血压患者血压变异性与早期肾损害相关性研究

Association between blood pressure variability and early kidney injury in patients with primary hypertension

目的探讨原发性高血压患者早期肾损害与血压变异性的关系。方法将高血压患者105例,行尿微量白蛋白、尿肌酐、肾功能、血糖及血脂、动态血压检测。将患者分为单纯高血压组(UACR<30mg/g),50例和高血压早期肾损害组(30<UACR<300mg/g),55例。结果高血压早期肾损害组24h平均收缩压、日间平均收缩压、24h收缩压标准差、日间收缩压标准差明显高于单纯高血压患者。多元线性回归分析发现24h平均收缩压、24h收缩压标准差是UACR的影响因素。结论高血压患者BPV升高与早期肾损害密切相关。

Objective To investigate the association between blood pressure variability and early kidney injury in patients with primary hypertension.Methods s A total of 105 patients with hypertension were enrolled,and urinary microalbumin,urine creatinine,renal function,blood glucose,and blood lipids were measured for all patients.Ambulatory blood pressure monitoring was also performed.The patients were divided into hypertension group with 50 patients[urinary albumin-to-creatinine ratio(UACR)<30 mg/g]and hypertension-early kidney injury group with 55 patients(30 mg/g<UACR<300 mg/g).Results Compared with the hypertension group,the hypertension-early kidney injury group had significantly higher 24-hour mean systolic blood pressure,mean daytime systolic blood pressure,24-hour systolic blood pressure standard deviation,and daytime systolic blood pressure standard deviation.The multivariate linear regression analysis showed that 24-hour mean systolic blood pressure and 24-hour systolic blood pressure standard deviation were influencing factors for UACR.Conclusion The increase in blood pressure variability is associated with early kidney injury in patients with hypertension.