探讨干扰素与炎唬宁联合治疗手足口病对患儿血清细胞因子、免疫球蛋白水平的影响

Influence on serum cytokines and immunoglobulin levels of hand foot and mouth disease with treatment of interferon and Yan Ning

目的探讨在手足口患儿的治疗中,干扰素与炎唬宁联合对患儿免疫球蛋白水平以及血清细胞因子的影响。方法此次选取的92例研究对象均为本院儿科接诊的手足口病患儿,对其按照抛硬币的方式进行随机分组:参照组(46例)和治疗组(46例)。两组患儿均通过干扰素进行治疗,治疗组在该基础上添加炎唬宁进行治疗,对两组患儿的免疫球蛋白水平、血清细胞因子以及总有效率进行探讨分析。结果用药后,治疗组的免疫球蛋白水平指标IgA、IgG、IgM均明显高于参照组,血清细胞因子指标白细胞介素IL-1β、IL-6、IL-10和肿瘤坏死因子TNF-α均明显低于参照组,治疗组的总有效率为93.48%,明显高于参照组(总有效率为71.74%),差异有统计学意义(P<0.05)。结论在手足口病患儿的治疗中,炎唬宁联合干扰素可以有效提升免疫球蛋白水平,降低血清细胞因子,其临床效果优异,值得临床借鉴及推广。

Objective To investigate the effects of interferon and Yan Ning on the level of immunoglobulin and serum cytokines in the treatment of children with hand foot and foot.Methods 92 cases of hand foot and mouth disease were selected in our hospital,and they were randomly divided into two groups according to the way of coin tossing:treatment group(46 cases)and reference group(46 cases).The two groups of children were treated with interferon,and the treatment group was treated with Yan Ning on the basis of the treatment.The immunoglobulin level,serum cytokine and the total effective rate of the two groups were analyzed.Results After treatment,the levels of IgA,IgG and IgM in the treatment group were significantly higher than those in the reference group.Serum cytokines,interleukin IL-1β,IL-6,IL-10 and tumor necrosis factor TNF-αlevels were significantly lower than those in the reference group.The total effective rate of the treatment group was 93.48%,which was significantly higher than that of the reference group(71.74%),the difference was statistically significant(P<0.05).Conclusion In the treatment of children with hand foot and mouth disease,Yan hung Ning combined with interferon can effectively improve the level of immunoglobulin and reduce serum cytokine,and its clinical effect is excellent.It is worthy of clinical reference and promotion.