摘要
水通道蛋白4抗体(anti-aquaporin 4antibody,AQP4-IgG)是能与细胞膜表面的水通道蛋白4(aquaporin 4,AQP4)特异性结合的抗体,是由LENNON等[1]于2005年在视神经脊髓炎(neuromyelitis optica,NMO)患者的血清中首次发现。AQP4抗体对NMO诊断的高度特异性,也使其成为了一种独立的疾病,并在此基础上延伸出了视神经脊髓炎谱系疾病(neuromyelitis optica spectrum disorders,NMOSD)这一概念。但并非所有的NMOSD患者都合并AQP4抗体,并且该抗体也可能参与了其他类型中枢神经系统脱髓鞘疾病的发病,如多发性硬化(multiple sclerosis,MS)及Balo同心圆硬化(Balo’s concentric sclerosis,BCS),本文围绕AQP4抗体的致病机制,检测方法以及与这些疾病的关系作以综述。
Anti aquaporin 4 antibody binds specifically to Aquaporin 4 on the cell membrane,this antibody was first discovered by Lennon in 2005 in the serum of patients with neuromyelitis optica(NMO).The high specificity of AQP4 IgG for the diagnosis of NMO also makes it an independent disease,and expands it to neuromyelitis optica spectrum disorders(NMOSD).However,not all NMOSD patients have AQP4 IgG,and this antibody also involves in the pathogenesis of other types of demyelinating diseases of the central nervous system,such as multiple sclerosis(MS)and Balo's concentric sclerosis(BCS).This article reviews the pathogenic mechanism of AQP4 IgG,its detection methods and the relationship with these diseases.
作者
李娇
商秀丽
LI Jiao;SHANG Xiuli(Department of Neurology,the First Hospital of China Medical University,Shenyang 110001,China)
出处
《中国实用神经疾病杂志》
2018年第13期1499-1504,共6页
Chinese Journal of Practical Nervous Diseases
