妊娠早期单纯甲状腺过氧化酶抗体阳性孕妇的妊娠结局(72例)

The Analysis of Pregnancy Outcome in 72 Pregnant Women with Thyroid Peroxidase Autoantibodies in First Trimester of Pregnancy

目的探讨妊娠早期甲功正常甲状腺过氧化酶抗体阳性对孕妇妊娠结局的影响。方法回顾性分析2016年3月至2017年12月在妇产科门诊建档的孕妇资料,选取单纯甲状腺过氧化酶抗体阳性孕妇72例设为试验组,另选同期健康孕妇68名为对照组,比较两组随妊娠进展,甲状腺功能变化和妊娠结局。结果至妊娠中晚期,试验组14例(19.4%)出现甲状腺功能紊乱,其中8例(11.1%)为亚临床甲减,6例(8.3%)为临床甲减,与对照组比较,差异有统计学意义(P<0.05)。试验组胎膜早破15例(20.8%),与对照组比较,差异有统计学意义(P<0.01)。试验组围生儿胎儿窘迫17例(23.6%),流产11例(15.3%),与对照组比较,差异有统计学意义(P<0.05)。结论妊娠早期单纯甲状腺过氧化酶抗体阳性可导致孕中晚期孕妇出现甲状腺功能紊乱和各种不良妊娠结局,应在临床工作中对此类孕妇加以重视。

Objective To investigate the influence of thyroid peroxidase autoantibodies in first trimester of pregnancy on pregnancy outcome.Methods The data of cases of pregnant women from department of obstetrics and gynecology were Retrospectivety analyzed from March 2016 to December 2017.72 TPOAb(+)pregnant women were Selected as research group,and 68 TPOAb(-)pregnant women were recruited as control group.Compared the thyroid function and pregnancy outcome between two groups.Results In medium and late pregnancy,14(19.4%)women in research group showed the thyroid dysfunction,8(11.1%)women were subclinical hypothyroidism,6(8.3%)women were clinical hypothyroidism,Compared to the control group,the difference was significantly(P<0.05).The incidence rate of premature rupture of membranes in research group(15,20.8%)were much higher than control group(P<0.01).The number of fetal distress(17,23.6%)and miscarriage(11,15.3%)were both higher in research group than control group(P<0.05).Conclusion Thyroid peroxidase autoantibodies can lead thyroid dysfunction and various adverse pregnancy outcomes,we should pay more attention to these type of pregnant women in clinical practice.