外泌体在结直肠癌中的作用

Roles of Exosomes in Colorectal Cancer

外泌体是细胞释放的细胞外囊泡,包含m RNA、mi RNA、蛋白质和部分特定区域的DNA等,参与细胞间通讯,并涉及许多生物学和病理学过程。来源于结直肠癌(CRC)细胞的外泌体与肿瘤的发生、肿瘤细胞的存活、增殖、侵袭和转移有关。本文介绍了外泌体及其纯化,并对CRC来源的外泌体种类、作用及其机制进行了综述。

Exosomes are small membranous vesicles secreted by a number of cell types and contain mRNAs,miRNAs,proteins and DNA fragments.Exsomes play a role in a variety of biological processes including cell-cell signaling and transfer of pathogens between cells.Exosomes derived from colorectal cancer(CRC)cells are involved in tumorigenesis,and survival,proliferation,invasion and metastasis of tumor cells.This article describes exosomes and their purification,and summarizes the types,roles,and mechanisms of CRC-derived exosomes.