依折麦布联合瑞舒伐他汀对老年动脉粥样硬化患者斑块及血脂的影响

Effect of ezetimibe combined with rosuvastatin on plaques and blood lipids in elderly patients with atherosclerosis

目的:探讨依折麦布联合瑞舒伐他汀对老年动脉粥样硬化患者斑块及血脂达标情况的影响作用。方法:将295例老年动脉粥样硬化患者随机分为观察组165例和对照组130例,观察组给予依折麦布联合瑞舒伐他汀进行治疗,对照组给予瑞舒伐他汀进行治疗,观察两组患者斑块和血脂水平改善情况。结果:治疗后观察组患者甘油三脂(triglyceride,TG)、胆固醇(cholesterol,TC)、低密度脂蛋白(low density lipoprotein,LDL-C)水平较治疗前均降低(P<0.05),其中TC、LDL-C水平降低程度优于对照组(P<0.05);治疗前后两组患者颈内动脉中膜厚度(medial membrane thickness of the internal carotid artery,IMT)比较差异无统计学意义(P>0.05),治疗后两组患者颈动脉粥样硬化斑块横切面最大面积(Smax)比较差异有统计学意义(P<0.05)。结论:依折麦布联合瑞舒伐他汀治疗老年动脉粥样硬化能够降低血脂水平,缩小粥样硬化斑块。

Objective:To investigate the effect of ezetimibe combined with rosuvastatin on plaques and blood lipids in elderly patients with atherosclerosis.Methods:295 elderly patients with atherosclerosis were chosen and randomly divided into the observation group(165 patients)and the control group(165 patients).The observation group were treated with ezetimibe combined with rosuvastatin while the control group were treated with rosuvastatin,with the plaques and blood lipids observed.Results:After treatment,the levels of triglyceride(TG),cholesterol(TC)and low density lipoprotein(LDL-C)in the observation group were significantly reduced,and the levels of TC and LDL-C were significantly lower than those in the control group(P<0.05).There was no significant difference in medial membrane thickness of the internal carotid artery(IMT)between the two groups before and after treatment(P>0.05).After treatment,the difference of Smax between the two groups was statistically significant(P<0.05).Conclusion:Ezetimibe combined with rosuvastatin can reduce blood lipid levels and atherosclerotic plaques in elderly patients with atherosclerosis.