东莞地区青少年骨龄调查研究与应用

Investigation and application of bone age in adolescents in Dongguan

目的:探讨东莞地区青少年骨龄发育状况及趋势。方法:采取分层整群抽样方法,随机选择东莞康华医院2014年6月至2017年5月因外伤或非生长发育异常状况的1 986例青少年(6~18岁)作为研究对象,根据年龄、性别进行分组并分别依据《中国青少年儿童手腕骨成熟度及评价方法》测定骨龄,评价与时间年龄的相关性。结果:除18岁组以外,男性各年龄段组骨龄均大于生活年龄(P<0.05);对于女性而言,6岁组、7岁组骨龄小于生活年龄(P<0.05),8岁组及18岁组骨龄与生活年龄间差异无统计学意义(P>0.05),其余各年龄段骨龄均大于生活年龄(P<0.05)。就骨龄而言,10岁及10岁以前,除8岁组外,男性骨龄均大于女性(P<0.05),10岁以后,除11岁组、12岁组及15岁组差异无统计学意义(P>0.05),各年龄段男性骨龄均小于女性(P<0.05)。就骨龄与生活年龄差值而言,8岁及8岁以前,男性骨龄与生活年龄差值均大于女性(P<0.05),而8岁以后,除9岁组、16岁组、18岁组差异无统计学意义(P>0.05),男性骨龄与生活年龄差值均小于女性(P<0.05)。线性回归分析建立不同性别骨龄推断生活年龄的回归方程:男性Y=0.9905X-0.0501,相关系数r=0.996(P<0.001);女性Y=0.9775X+0.1213,相关系数r=0.995(P<0.001)。结论:东莞地区青少年多个年龄组骨龄高于生活年龄,10岁以前女性骨龄多低于男性,13岁后女性骨龄多大于男性。男、女骨龄与生活年龄存在较好的线性关系。

Objective:To explore the development and the trend of bone age in adolescents in Dongguan.Methods:1986 adolescents(6~18 years old)with abnormal conditions of the growth and development due to trauma from June 2014 to May 2017 hospitalized in Dongguan Kanghua Hospital were randomly chosen as the research object by stratified sampling and cluster sampling and divided into different groups according to ages and sexes,with bone age measured and its correlation with age evaluated according to Chinese Adolescents'Wrist Maturity and the Evaluation Methods.Results:Except for the 18-years-old group,the bone age of the males in all age groups was older than their age(P<0.05).For the females,the bone age of the 6-year-old group and the 7-year-old-group was younger than their age(P<0.05).There was no significant difference in bone age in the 8-year-old group and the 18-year-old group(P>0.05);the bone age of other age groups was older than their age(P<0.05).As far as bone age was concerned,in the less than 10-year-old group(including 10 years old),except for the 8-year-old group,the male bone age was younger than that of the females(P<0.05).In the more than 10-year-old group,there was no difference in the 10-year-old group,the 11-year-old group and the 15-year-old group(P>0.05),but the age of the males was younger than that of the females(P<0.05).In terms of the difference between the bone age and the age,before and at the age of 8,the difference between male bone age and the age was greater than that of the females(P<0.05).And for those over 10 years old,there was no difference in the 9-year-old group,the 16-year-old group and the18-year-old group(P>0.05);the difference between the male bone age and age was less than that of the females(P<0.05).Regression equation of linear regression analysis was used to establish the regression equation of age and bone age in different sexes:male Y=0.9905x-0.0501,correlation coefficient R=0.996,female Y=0.9775x+0.1213,correlation coefficient R=0.995(P<0.001).Conclusion:The bone age in many age groups of adolescents in Dongguan is older than their age;before the age of 10,the female bone age was younger than that of the males;after the age of 13,the female bone age was older than that of the males;there is a good linear relationship between male and female bone age and their age.