应用阿片类药物癌痛病人的生活质量调查分析

STUDY OF QUALITY OF LIFE IN CANCER PAIN PATIENTS TREATED WITH OPIOIDS

目的 :了解应用阿片类药物治疗癌痛病人生活质量现状,分析阿片类药物对癌痛病人躯体功能、角色功能、情绪功能、认知功能及社会功能的影响,为今后对应用阿片类药物癌痛病人实施护理措施提供参考依据。方法 :采用病人一般情况调查表和生活质量测定量表(EORTC QLQ-C30中文版),对肿瘤科166例癌性疼痛病人生活质量和疼痛状态进行调查,并分析相关影响因素。结果 :应用阿片类药物治疗癌性疼痛病人的总体健康状况得分为52.54±20.72;应用阿片类药物的女性癌性疼痛病人躯体功能维度和失眠维度的得分高于男性病人(P<0.01);在职的研究对象总体健康状况、角色功能、情绪功能、认知功能、社会功能较不在职者得分较高(P<0.01);漏服阿片类药物的癌性疼痛病人的总体健康状况得分较无漏服阿片类药物病人低(P<0.001)。结论:性别、工作状态以及漏服阿片类药物对应用阿片类药物的癌痛病人的生活质量有影响。晚期癌症姑息治疗应关注病人生活质量的提高,缓解癌痛是提高生活质量的重要内容。

Objective:The aim of this study was to investigate the life quality of patients with cancer pain treated with opioids.The effects of opioids on various aspects were analyzed.This study could provide reference for future application of opioids in improving the life quality of cancer pain patients and implementing a more comprehensive nursing.Methods:One hundred and sixty-six patients in medical oncology of a hospital in Beijing participated in this study voluntarily and signed the informed consent.The general information questionnaire and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire(EORTC QLQ-C30)were used to assess the quality of life and the pain state of the patients.The related factors were also analyzed.Results:(1)The overall health score is 52.54±20.72.Among five function dimensions,the score of emotion function is the highest and the second one is physical function.Among the symptom dimensions,the scores of fatigue,pain and appetite loss were higher than others.(2)The scores of physical functions dimension and insomnia dimension in female patients were significantly higher than these in male patients when treated with opioids(P<0.01,P<0.05).(3)In the dimensions of general health state,role function,emotion function,cognitive function and social function,patients with job were significantly better than patients without job(P<0.05,P<0.01).(4)Compared with patients without drug missing,the scores of general health state,physical function,role function and social function in patients with drug missing were significantly lower(P<0.05,P<0.001).Meanwhile,the symptom scores of the patients with drug missing were significantly higher than these of patients without drug missing,including fatigue,pain,dyspnea,appetite loss and financial difficulty(P<0.05,P<0.01,P<0.001).Conclusion:Gender,work state and drug missing have effects on the quality of life in patients with cancer pain treated with opioids.