CIK细胞联合顺铂胸腔注射对胸膜肿瘤微环境VEGF及TGF表达的影响

目的探讨应用自体CIK细胞联合化疗药物胸腔局部注射治疗恶性胸腔积液的疗效。方法选取经过胸膜活检或胸腔积液肿瘤脱落细胞学阳性诊断恶性胸腔积液的病例62例,随机分为对照组和试验组,分别胸腔局部注射顺铂、顺铂+自体CIK细胞,观察胸膜组织肿瘤微环境中血管内皮生长因子(VEGF)、转化生长因子(TGF)等指标改变。结果试验组VEGF及TGF表达明显降低,且优于对照组(P<0.05),两组不良反应发生率无统计学差异(P>0.05)。结论自体CIK联合顺铂胸腔内注入对恶性胸腔积液的治疗效果明显高于单独使用化疗药物。

Objective To observe the effect of applicating autologous CIK Cell combined chemotherapy thoracic local injection in the treatment of malignant pleural effusion disease.Methods Totally 62 patients with malignant plerual effusion diagnosed by pleural biopsy and cytology of pleural effusion were randomly divided into two groups.For patients in the control group was given cisplatin.For patients in the study group was given combined the CIK cells.Then observing the changes of indexes,such as VEGF and TGF,in thoracic tissue cells tumor microenvironment cisplatin.Results The VEGF and TGF indexes of cases in study group significantly decreased,which was better than the result in control group(P<0.05).There was no significant difference in the incidence rate of adverse reactions between the two groups(P>0.05).Conclusion The therapeutic efficacy of thoracic local injecting autologous CIK with Cisplatin is apparently better than applicating chemotherapy itself in the treatment of malignant pleural effusion of thoracic lesions.