艾司西酞普兰治疗抑郁症513例疗效观察

目的探讨艾司西酞普兰治疗抑郁症的临床疗效。方法选择2016年1月至2017年1月使用度洛西汀治疗抑郁症50例(A组)和使用艾司西酞普兰治疗抑郁症513例(B组)作为研究对象。度洛西汀口服剂量为60mg/d,艾司西酞普兰剂量为10mg/d。两组患者均治疗6周。结果B组和A组患者在诊疗6周后的抑郁量表评分分别为(5.96±3.15)分和(6.1±3.22)分,相较于治疗前的(23.87±3.08)分和(24.16±2.88)分,明显下降(P<0.05)。结论艾司西酞普兰和度洛西汀均能有效治疗抑郁症,且起效均较快,但艾司西酞普兰治疗的不良反应发生率相较于度洛西汀更少。

Objective To explore the clinical effect of duloxetine and alcitalopram for clinical depression.Methods Totally 50 patients with depression(group A)and 513 patients with depression(group B)were selected as the study subjects from January 2016 to January 2017.Duloxetine was used for treatment of group A(60 mg/d),escitalopram was used for group B(10 mg/d).The duration of the treatment was 6 weeks in both groups.Results The clinical depression scale of the two groups was(5.96±3.15)points,(6.1±3.22)points,which was significantly lower than that of the diagnosis(23.87±3.08)points,(24.16±2.88)points.Conclusion The duloxetine and escitalopram can be effective in the treatment of depression.However,the incidence of adverse reactions in patients with estalcitalo pram was less than that of duloxetine.