丹红注射液配合胸腔闭式引流加四联抗结核药物治疗结核性胸腔积液的效果

Effect of Danhong Injection combined with closed thoracic drainage plus four anti-tuberculous drugs in treating tuberculous pleural effusion

目的探讨丹红注射液配合胸腔闭式引流加四联抗结核药物治疗结核性胸腔积液的效果。方法选择沈阳市第十人民医院2017年1~6月80例诊断明确初治结核性胸腔积液患者临床资料,依据治疗方式不同分为对照组(四联抗结核药物治疗,40例)和联合治疗组(丹红注射液配合胸腔闭式引流加四联抗结核药物治疗,40例)。观察两组胸腔积液引流时间、引流总量、住院时间,观察两组患者治疗前后胸膜厚度、肺功能、胸液白介素-12(IL-12)、肿瘤坏死因子-α(TNF-α)、腺苷脱氨酶(ADA)含量情况及两组临床疗效。结果联合治疗组患者胸腔积液引流时间、住院时间均短于对照组(P<0.05)。治疗后对照组和联合治疗组胸膜厚度、IL-12、TNF-α、ADA低于治疗前,TLC、FVC、FEV1/FVC%均高于治疗前,且联合治疗组胸膜厚度、IL-12、TNF-α、ADA低于对照组,TLC、FVC、FEV1/FVC%均高于对照组,差异均有统计学意义(P<0.05)。联合治疗组临床治疗总有效率高于对照组(P<0.05)。结论采用丹红注射液配合胸腔闭式引流加四联抗结核药物治疗结核性胸腔积液,可以缩短引流时间,提高引流量,改善胸膜厚度、肺功能和胸液积液生化指标,提高临床疗效,值得临床推广应用。

Objective To explore Lhe effecL of Danhong InjecLion combined wiLh closed Lhoracic drainage plus four an-Li-Luberculous drugs in LreaLing Luberculous pleural effusion.Methods The 80 cases clinical daLa of early diagnose clearly Luberculous pleural effusion in Lhe TenLh People's HospiLal of Shenyang from January Lo June in 2017 were se-lecLed and divided inLo conLrol group(four anLi-Luberculosis drugs,40 cases)and combined LreaLmenL group(Danhong InjecLion cooperaLe Lhoracic close drainage and four anLi-Luberculosis drugs,40 cases)by differenL LreaLmenL meLhod.The pleural effusion drainage Lime,pleural effusion drainage volume and hospiLal sLays in Lhe Lwo groups were deLecLed,Lhe pleural Lhickness,lung funcLion and Lhe levels of IL-12,TNF-琢,ADA in Lhe Lwo groups before and afLer LreaLmenL were compared and Lhe clinical effecLs of Lwo groups were deLecLed.Results The pleural effusion drainage Lime,hospi-Lal sLays in Lhe combined LreaLmenL group were shorLer Lhan Lhose of Lhe conLrol group(P<0.05).AfLer LreaLmenL,Lhe pleural Lhickness and Lhe levels of IL-12,TNF-琢,ADA in Lhe Lwo groups were lower Lhan Lhose before LreaLmenL,and Lhe levels of TLC,FVC,FEV1/FVC%were higher Lhan before LreaLmenL,besides Lhe pleural Lhickness and Lhe levels of IL-12,TNF-琢,ADA in Lhe combined LreaLmenL group afLer LreaLmenL were lower Lhan Lhose in Lhe conLrol group,and Lhe levels of TLC,FVC,FEV1/FVC%were higher Lhan Lhose of Lhe conLrol group,wiLh sLaLisLically significanL difference(P<0.05).The clinical LreaLmenL LoLal effecLive raLe of combined LreaLmenL group was higher Lhan LhaL of Lhe conLrol group(P<0.05).Conclusion Danhong InjecLion wiLh closed Lhoracic drainage plus four anLi-Luberculosis drugs in Lhe LreaLmenL of Luberculous pleural effusion can shorLen Lhe Lime,increase Lhe flow,and improve pleural Lhickness,lung func-Lion and pleural effusion,biochemical indicaLors and Lhe clinical curaLive effecL,which is worLhy of clinical applicaLion.