口腔黏膜扁平苔藓患者幽门螺杆菌感染的相关分析

Correlation Analysis of Helicobacter Pylori Infection in Patients with Oral Lichen Planus

目的:分析口腔扁平苔藓患者幽门螺杆菌感染状况。方法:选取2016年3月-2017年10月笔者所在医院收治的口腔扁平苔藓患者共71例,所有患者均进行活检病理学确诊为扁平苔藓,另选取慢性炎症患者30例为对照组。所有患者均进行14C-尿素呼气试验方法及血清抗Hp抗体检测。结果:口腔扁平苔藓患者发病年龄多位于41~60岁,占69.01%,女性发病率高于男性,但差异无统计学意义(X2=1.350,P=0.245)。14C-尿素呼气试验中,扁平苔藓组Hp阳性患者48例,占67.60%,慢性炎症组为13例,占43.33%,两组比较差异有统计学意义(P<0.05)。血清抗Hp抗体检测中,扁平苔藓组Hp阳性患者37例,占52.11%,慢性炎症组为7例,占23.33%,两组比较差异有统计学意义(P<0.05)。结论:口腔扁平苔藓患者幽门螺杆菌感染率较高,并与口腔扁平苔藓患者存在相关性。

Objective:To analyze the Helicobacter pylori infection in patients with oral lichen planus.Method:A total of 71 patients with oral lichen planus were selected from March 2016 to October 2017.All patients were diagnosed with lichen planus by biopsy and pathology,and chronic inflammation group was selected as control group,and 30 cases were treated with oral lichen planus.The following tests were performed in all patients:the 14C-urea breath test,the detection of anti Hp antibody in serum.Result:The incidence of oral lichen planus was mostly 41-60 years old,accounting for 69.01%.The incidence of female patients was higher than that of men,the difference was not statistically significant(X^2=1.350,P=0.245).In the 14C-urea breath test,there were 48 cases of Hp positive in the lichen planus group,accounting for 67.60%,and 13 cases in the chronic inflammation group,accounting for 43.33%,the difference was statistically significant(P<0.05).In the detection of serum anti Hp antibody,37 cases of Hp positive patients in lichen planus group accounted for 52.11%,and 7 cases in chronic inflammation group accounted for 23.33%,the difference was statistically significant(P<0.05).Conclusion:The rate of Helicobacter pylori infection in patients with oral lichen planus is higher and is associated with patients with oral lichen planus.