白细胞介素-17在急性呼吸窘迫综合征患者外周血中的表达及意义

Expression and clinical significance of IL-17 in peripheral blood of ARDS patients

目的探讨白细胞介素-17(IL-17)对急性呼吸窘迫综合征(ARDS)病情评估的临床意义。方法选取35例sepsis-ARDS患者为研究对象,18例健康志愿者为对照组,酶联免疫吸附法(ELISA)检测其血浆的IL-17水平。分析sepsis-ARDS患者IL-17水平与氧合指数(PaO_2/FiO_2)和预后的关系。结果35例sepsis-ARDS患者血浆的IL-17水平明显升高。IL-17和PaO_2/FiO_2呈负相关。相对于存活组而言,死亡组IL-17水平升高更显著。结论 Sepsis-ARDS患者血浆IL-17水平明显增高,并且和PaO_2/FiO_2及存活率呈负相关。

Objective To explore the clinical significance of interleukin-17(IL-17)in evaluating the severity of acute respiratory distress syndrome(ARDS).Methods 35 patients with sepsis-ARDS were selected as the subjects and 18 healthy volunteers were chosen as control group.IL-17 in plasma was detected by ELISA.The relationship between IL-17 and oxygenation index(PaO2/FiO2)as well as prognosis in sepsis-ARDS patients were analyzed.Results(1)IL-17 increased significantly in 35 patients with sepsis-ARDS.(2)There was a negative relationship between IL-17 and PaO2/FiO2.Compared with the survival group,IL-17 in the death group increased more significantly.Conclusion IL-17 in sepsis-ARDS patients is significantly higher,and there is a negative correlation between IL-17 and PaO2/FiO2 and survival rate.