尖锐湿疣患者人乳头瘤病毒分型定量结果分析及临床意义

The clinical significance of human papillomavirus quantification and genotyping in patient with condyloma acuminatum

目的探讨人乳头瘤病毒(HPV)分型定量检测对于临床上诊治尖锐湿疣(CA)的指导意义。方法纳入2015年12月至2016年9月在南方医院皮肤科门诊就诊患者126例,所有患者均经临床检查确诊为CA,并经FQ-PCR检测为HPV阳性,对患者感染HPV型别及感染病毒量等参数进行回顾性分析。结果 126例患者中共检出20种基因型,以HPV6和HPV11型为主;低危组HPV平均病毒载量高于高危组;多重感染多见,占37.3%。对治疗过程中监测HPV型别和病毒载量的CA病例分析说明病毒载量变化可有效指导疗效判断。结论 HPV分型定量检测对于CA的诊断和疗效监测有着明确的指导意义。

Objective To investigate the clinical significance of HPV quantification and genotyping in the diagnosis and treatment of CA.Methods One hundred and twenty-six outpatients were enrolled in the retrospec-tive analysis.HPV genotypes and viral load were examined by FQ-PCR.Results Twenty HPV subtypes were determined.The most frequent genotype was HPV6 and HPV11.The average viral load of low-risk HPV was higher than that of high-risk HPV.Multiple infection was common and accounts for 37.3%.The case analysis indicated that monitoring the changes in viral load can effectively guide curative effect.Conclusion There is a clear guiding significance of HPV quantification and genotyping for the diagnosis and efficacy monitoring of CA.