肝微环境在消化系肿瘤肝转移中的作用及调控机制

Role of liver microenvironment in liver metastasis of digestive system malignancies and the underlying mechanism

肝因其丰富的血供和特殊的解剖位置,是消化系肿瘤最常见的转移部位。近年的研究发现,肝转移前微环境的调控,如各种细胞的活化、免疫反应的调节和细胞因子水平的变化,在消化系肿瘤肝转移的发生和发展中起着决定性的作用。针对肝微环境开展肿瘤免疫治疗,或许可以为消化系肿瘤肝转移的防治提供新的思路。

The liver is the most common metastatic site of digestive system malignancies,mainly due to its special anatomical position and rich blood supply.Growing evidence has showed that the pre-metastatic microenvironment of the liver,such as activation of various cells,modification of immune response,and adjustment of cytokine concentrations,plays an essential role in the occurrence and progression of liver metastasis of digestive tract malignancies.Targeting the pre-metastatic microenvironment of the liver during cancer immunotherapy appears to be a new strategy for preventing and managing liver metastasis of digestive system malignancies.