急性左心衰患者NPPA基因多态性与NT-proBNP相关性研究

Correlation between NPPA gene polymorphism and NT-proBNP in patients with acute left heart failure

目的探讨急性左心衰患者心房利钠肽前体A(NPPA)基因多态性及N末端脑钠肽前体(NT-proBNP)间的关联性。方法选自2016年5月~2017年10月间,于东莞市虎门医院心内科治疗的急性左心衰患者53例(观察组),同期选择我院体检的健康人群53例(对照组),比较两组NPPA基因多态性及NT-proBNP的表达情况。结果两组比较发现,观察组中患者rs5063基因型和rs5065基因型中的AA基因型及AG基因型患者例数远高于对照组,P<0.05;两组rs5063基因型和rs5065基因型患者的NT-proBNP水平相比无显著差异(P>0.05),但AA+GA基因型患者的NT-proBNP远低于GG基因型患者,P<0.05。结论急性左心衰患者体内的NPPA基因多态性与NT-proBNP间有较强关联性,其中AA+GA基因型患者的NT-proBNP增高更为明显,临床中应予以重视。

Objective To investigate the correlation between gene polymorphism of natriuretic peptide precursor A(NPPA)and N-terminal pro-brain natriuretic peptide(NT-proBNP)in patients with acute left heart failure.Methods The patients with acute left heart failure(n=53,observation group)were chosen from Department of Cardiology of Humen Hospital in Dongguan City from May 2016 to Oct.2017,and health subjects(n=53,control group)were chosen from the same hospital at the same time.The gene polymorphism of NPPA and expression of NT-proBNP were compared between 2 groups.Results The comparison between 2 groups showed that the patients with AA genotype and AG genotype in rs5063 genotype and rs5065 genotype were significantly more in observation group than those in control group(P<0.05).The level of NT-proBNP had no significant difference in patients with rs5063 genotype and rs5065 genotype between 2 groups(P>0.05).But the level of NT-proBNP was significantly lower in patients with AA+GA genotype than that in patients with GG genotype(P<0.05).Conclusion The gene polymorphism of NPPA and expression of NT-proBNP are significantly correlated to each other in patients with acute left heart failure,and level of NT-proBNP is much higher in patients with AA+GA genotype,which should be highly noticed in clinic.