小剂量腹膜透析对慢性肾衰竭的效果研究

Study on the Effect of Small Dose Peritoneal Dialysis on Chronic Renal Failure

目的研究小剂量初次腹膜透析对慢性肾衰竭患者残余肾功能的影响。方法研究时间为2016年1—12月,研究对象选择56例就诊于我院的慢性肾衰竭患者,应用数字随机表法将患者随机分为两组各28例,对照组采用常规剂量(8 000 ml/d)进行初次腹膜透析治疗,观察组采用小剂量(5 000 ml/d)进行初次腹膜透析治疗,比较两组的临床疗效、肾功能指标、不良反应。结果两组的临床总有效率比较差异无统计学意义(P>0.05),且治疗后两组的BUN、Scr均较治疗前降低(P<0.05),而组间比较均差异无统计学意义(P>0.05)。在不良反应方面,两组间差异无统计学意义(P>0.05)。结论对慢性肾衰竭患者实施小剂量初次腹膜透析治疗,在确保临床疗效、保护残余肾功能的同时,并未明显增加不良反应。

Objective To investigate the effect of small dose primary peritoneal dialysis on residual renal function in patients with chronic renal failure.Methods From January to December 2016,56 patients with chronic renal failure in our hospital were selected,randomly divided the patients into two groups with 28 patients in each group.In the control group,the initial peritoneal dialysis was performed at a dose(8 000 ml/d).The observation group was treated with a small dose(5 000 ml/d)for initial peritoneal dialysis.Clinical efficacy,renal function,and adverse reactions were compared between the two groups.Results There was no significant difference in clinical total effective rate between the two groups(P>0.05).After treatment,both BUN and Scr were lower than before treatment(P<0.05),but there was no statistically significant difference between the two groups(P>0.05).In terms of adverse reactions,there was no significant difference between the two groups(P>0.05).Conclusion The treatment of patients with chronic renal failure with small dose primary peritoneal dialysis does not significantly increase adverse reactions while ensuring clinical efficacy and protecting residual renal function.