TNIP1基因rs7708392多态性与动脉粥样硬化相关性研究

Association of rs7708392 Polymorphism in TNIP1 Gene with Atherosclerosis

目的探讨TNIP1基因上rs7708392位点多态性与动脉粥样硬化风险的关联性。方法本实验收集具有颈部血管影像学检查的病例入组,其中动脉粥样硬化组264例,对照组320例,采用Sequennom MassARRAY分子量阵列技术对rs7708392基因位点进行分型,利用SNPstats统计平台和SPSS软件分析该位点在等位基因频率和五种基因模型下(共显性模型、显性模型、隐性模型、加性模型、超显性模型)与动脉粥样硬化风险的相关性。结果在校正年龄和性别后,整体分析rs7708392变异在等位基因及五种遗传模型下与动脉粥样硬化风险均差异无统计学意义。男性亚组分析发现rs7708392位点在杂合子模型(OR=1.80,95%CI 1.06~3.05)、显性模型(OR=1.89,95%CI1.13~3.16)及加性模型下(OR=1.79,95%CI 1.14-2.82)与动脉粥样硬化的发病风险具有相关性。结论TNIP1基因上的rs7708392位点可能与动脉粥样硬化的发病风险相关。

Objective To evaluate the association between the risk of atherosclerosis and rs7708392 polymorphismin TNIP1gene.Methods Thepresentstudy collected population with imaging examination of carotid artery.A total of 264 atherosclerosis patients and 320 healthy controls were included.SequenomMassARRY system was used to classifythe rs7708392 genotype.Association analyses were performed in SNPstats platform and SPSS softwareunder five genetic models(dominant,recessive,additive,codominant,overdominant)and allele frequency.Results After adjustment for age and gender,rs7708392 variant were detected to be not associated withatherosclerosissusceptibility under allele frequencyor five genetic models.Based on gender subgroup analysis,in male subgroup,the risk of atherosclerosis increased in the heterozygous(OR=1.8,95%CI 1.06-3.05),dominant(OR=1.89,95%CI 1.13-3.16)and additive(OR=1.79,95%CI 1.14-2.82)model.Conclusion Our research showed that rs7708392 polymorphism is probably associated with an increased risk of atherosclerosis in male population.