氟伐他汀联合贝那普利对老年慢性心力衰竭患者的影响

Impact of Fluvastatin Combined with Benazepril on Elderly Patients with Chronic Heart Failure

目的探讨氟伐他汀联合贝那普利对老年慢性心力衰竭患者的影响。方法选取2015年2月—2017年1月石家庄市鹿泉人民医院收治的老年慢性心力衰竭患者156例,采用随机数字表法分为对照组和观察组,每组78例。在标准抗心力衰竭治疗等常规治疗基础上,对照组患者给予贝那普利治疗,观察组患者在对照组基础上加用氟伐他汀治疗;两组患者均连续治疗6个月。比较两组患者治疗前后6分钟步行距离、美国纽约心脏病协会(NYHA)分级、心功能指标及血浆同型半胱氨酸(Hcy)、N末端B型利钠肽前体(NT-proBNP)、瘦素(Leptin)水平,并观察两组患者治疗期间不良反应发生情况。结果治疗前后两组患者6分钟步行距离及NYHA分级比较,差异无统计学意义(P>0.05)。治疗前两组患者左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)比较,差异无统计学意义(P>0.05);治疗后观察组患者LVEF高于对照组,LVEDD、LVESD短于对照组(P<0.05)。治疗前两组患者血浆Hcy、NT-proBNP、Leptin水平比较,差异无统计学意义(P>0.05);治疗后观察组患者血浆Hcy、NT-proBNP、Leptin水平低于对照组(P<0.05)。两组患者治疗期间不良反应发生率比较,差异无统计学意义(P>0.05)。结论氟伐他汀联合贝那普利对老年慢性心力衰竭患者运动耐量及心力衰竭严重程度的改善作用有限,但可有效改善患者心功能,降低血浆Hcy、NT-proBNP、Leptin水平,且安全性较高。

Objective To investigate the impact of fluvastatin combined with benazepril on elderly patients with chronic heart failure.Methods A total of 156 elderly patients with chronic heart failure were selected in the People's Hospital of Luquan from February 2015 to January 2017,and they were divided into control group and observation group according to random number table,each of 78 cases.Based on conventional(including standard anti-heart failure treatment),patients in control group received benazepril,while patients in observation group received fluvastatin combined with benazepril;both groups continuously treated for 6 months.Observation index including 6-minute walking distance,NYHA grade,index of cardiac function,plasma levels of Hcy,NT-proBNP and Leptin was compared between the two groups before and afrer treatment,and incidence of adverse reactions during treatment was observed.Results No statistically significant differences of 6-minute walking distance or NYHA grade was found between the two groups before or after treatment(P>0.05).No statistically significant differences of LVEF,LVEDD or LVESD was found between the two groups before treatment(P>0.05);after treatment,LVEF in observation group was statistically significantly higher than that in control group,while LVEDD and LVESD in observation group were statistically significantly shorter than those in control group(P<0.05).No statistically significant differences of plasma level of Hcy,NT-proBNP or Leptin was found between the two groups before treatment(P>0.05),while plasma levels of Hcy,NT-proBNP and Leptin in observation group were statistically significantly lower than those in control group after treatment(P<0.05).No statistically significant differences of incidence of adverse reactions was found between the two groups during treatment(P>0.05).Conclusion Fluvastatin combined with benazepril has limit improvement effect on exercise tolerance and severity of heart failure in elderly patients with chronic heart failure,but can effectively improve the cardiac function,reduce the plasma levels of Hcy,NT-proBNP and Leptin,with relatively high safety.