粪菌移植在胃肠疾病及非胃肠疾病临床应用研究的证据现状

Clinical Application of Fecal Microbiota Transplantation in Gastrointestinal Diseases and Non-gastrointestinal Diseases:a Literature Review

粪菌移植(FMT)是指将来自健康供者的粪便微生物群通过各种方法移植到患者的胃肠道中,目的是恢复患者正常的微生物群并治疗疾病。FMT最有效和最充分的研究指征是复发性难辨梭菌感染(rCDI)。目前正在探索FMT作为其他胃肠疾病的潜在疗法,如炎症性肠病(IBD)、肠易激综合征(IBS)等;虽然尚无足够证据推荐FMT用于非胃肠疾病,如慢性疲劳综合征、帕金森病、肥胖和代谢综合征,以及多发性硬化症等,但是FMT在非胃肠疾病治疗方面正在迅速兴起。因此,本文主要综述FMT临床应用研究的证据现况。

Fecal microbiota transplantation(FMT)is the transfer of fecal bacteria from a healthy donor into the colon of a patient whose disease is a result of an altered microbiome,with the goal of restoring the normal microbiota and thus curing the disease.We mainly reviewed and summarized the clinical application of FMT recently:so far,sufficient evidences show that FMT is the most effective treatment for recurrent Clostridium difficile infection.Moreover,it is being exploratorily used as a potential therapy for other gastrointestinal diseases such as inflammatory bowel disease,irritable bowel syndrome and so on.Furthermore,although there is no adequate evidences supporting FMT for chronic fatigue syndrome,Parkinson's disease,metabolic disorders,multiple sclerosis and other non-gastrointestinal diseases,relevant studies are increasing rapidly.This article mainly reviewed the current evidences of clinical application of FMT.