慢性肾脏病患者肠道菌群的变化及影响研究

Alterations and Influences of Gut Microbiota in Chronic Kidney Disease

正常情况下,肠道菌群与人体处于互利共生状态。慢性肾脏病(CKD)可引起肠道菌群失调、肠道屏障功能受损,导致肠道菌群移位、尿毒症毒素产生过多和全身炎性反应,加速CKD进展。肠道菌群参与CKD发生发展的机制尚不明确,本文就CKD患者肠道菌群的变化及影响做一综述,希望通过调节肠道菌群延缓CKD进展以降低病死率。

Normally the gut microbiota and the human body are mutually beneficial.Chronic kidney disease(CKD)contributes to the intestinal dysbiosis and impaired intestinal barrier resulting in bacterial translocation,increased production of uremic toxin and systemic inflammation,which accelerates the progression of CKD.The exact pathogenesis by which gut microbiota participates in the development of CKD is not clear.This paper reviews literature on the alterations and influences of gut microbiota in CKD in order to provide basis for delaying the progression of CKD and decreasing its mortality by modulating gut microbiota.