新疆地区汉族和维吾尔族及哈萨克族原发性高血压病患者血清转化生长因子β1影响因素研究

Influencing Factors of Serum Transforming Growth Factor-β1 in Han,Uyghur,and Kazak Patients in the Xinjiang Uygur Autonomous Region

目的探讨新疆地区汉族、维吾尔族、哈萨克族原发性高血压病患者血清转化生长因子β1(TGF-β1)的影响因素。方法选取2014年9月—2016年5月在新疆医科大学第一附属医院高血压科住院的原发性高血压病患者271例(其中汉族129例、维吾尔族70例、哈萨克族72例),收集患者一般资料及实验室检查指标结果。分析3个民族患者血清TGF-β1水平与一般资料及实验室检查指标的相关性。对3个民族血清TGF-β1水平的相关因素进行多元线性回归分析。结果相关性分析显示,汉族患者的血清TGF-β1水平与收缩压、舒张压、心率呈正相关(r=0.216、0.236、0.194,P<0.05);维吾尔族患者的血清TGF-β1水平与肌酐、血清胱抑素C、尿微量清蛋白水平呈正相关(r=0.429、0.446、0.446,P<0.05),与估算肾小球滤过率(eGFR)呈负相关(r=-0.446,P<0.05);哈萨克族患者的血清TGF-β1水平与三酰甘油、空腹血糖水平呈正相关(r=0.446、0.384,P<0.05)。多元线性回归分析显示,汉族患者的血清TGF-β1水平与舒张压(β=0.216)相关;维吾尔族患者的血清TGF-β1水平与血清光抑素C(β=0.531)水平、eGFR(β=-0.448)、尿微量清蛋白水平(β=0.603)相关;哈萨克族患者的血清TGF-β1水平与三酰甘油(β=0.469)、空腹血糖(β=0.248)、肌酐水平(β=0.315)及尿钠/尿钾(β=0.528)相关。结论舒张压与汉族原发性高血压病患者血清TGF-β1水平相关;血清胱抑素C水平、eGFR、尿微量清蛋白水平与维吾尔族患者血清TGF-β1水平相关;三酰甘油、空腹血糖、肌酐水平及尿钠/尿钾与哈萨克族患者血清TGF-β1水平相关。

Objective To investigate the influencing factors of serum transforming growth factor-β1(TGF-β1)in Han,Uyghur,and Kazak individuals with essential hypertension in the Xinjiang Uygur Autonomous Region.Methods A total of 271 patients(Han,129 cases;Uyghur,70 cases;Kazak,72 cases)with hypertension admitted to the First Affiliated Hospital of Xinjiang Medical University from September 2014 to May 2016 were recruited for the study.The clinical data of the patients were collected.The correlation between serum TGF-β1 and clinical indices in the three ethnic groups were analyzed,the related factors of TGF-β1 were analyzed using multivariate linear regression.Results Serum TGF-β1 levels were positively correlated with systolic blood pressure,diastolic blood pressure,and heart rate in the Han patients(r=0.216,0.236,0.194,P<0.05);serum TGF-β1 level was positively correlated with creatinine,serum cystatin C,and urinary microalbumin in the Uygur patients(r=0.429,0.446,0.446,P<0.05),and negatively correlated with eGFR in the Uygur patients(r=-0.446,P<0.05).In the Kazak patients,serum TGF-β1 levels showed positive correlations with triglyceride and fasting blood glucose(r=0.446,0.384,P<0.05).Multivariate linear regression analyses showed that the serum TGF-β1 level was independently associated with diastolic blood pressure(β=0.216)in Han patients,and serum cystatin C(β=0.531),eGFR(β=-0.448),and urinary microalbumin(β=0.603)in the Uygur patients.Triglyceride(β=0.469),fasting blood glucose(β=0.248),creatinine(β=0.315),and urinary sodium/urinary potassium(β=0.528),were associated with TGF-β1 levels in the Kazak patients.Conclusion Diastolic blood pressure was independently associated with TGF-β1 levels in Han patients;serum cystatin C,eGFR,and urinary microalbumin were independently associated with TGF-β1 levels in Uighur patients;triglyceride,fasting blood glucose,creatinine,and urinary sodium/urine potassium were independently associated with serum TGF-β1 levels in Kazak patients.