左氧氟沙星联合头孢他啶治疗尿路感染的临床疗效

Clinical Efficacy of Levofloxacin Combined with Ceftazidime in the Treatment of Urinary Tract Infection

目的:探讨尿路感染采用左氧氟沙星联合头孢他啶的治疗效果。方法:以信阳市中心医院2015年12月至2017年10月126例尿路感染患者为研究对象,根据平均、随机原则分组,对照组及观察组各63例。对照组采取左氧氟沙星治疗,观察组使用左氧氟沙星联合头孢他啶治疗。观察两组症状改善、复发、细菌清除及不良事件发生情况。结果:观察组退热时间、尿急及尿痛缓解时间、尿菌转阴时间分别为(2.02±0.45)d、(4.61±1.16)d、(2.57±0.43)d,均低于对照组,P<0.05:观察组复发概率、细菌清除概率分别为1.59%、98.41%,低于对照组,P<0.05:观察组不良事件发生概率(7.94%)与对照组相比无显著差异,P>0.05。结论:尿路感染予以左氧氟沙星联合头孢他啶治疗,临床价值较高,可显著控制病情,降低复发风险。

Objective:To explore the therapeutic effect of levofloxacin combined with ceftazidime in urinary tract infection.Methods:Taking 126 patients with urinary tract infection from December 2015 to October 2017 in our hospital as the study object,according to the average and random principle,63 cases in the control group and 63 cases in observation group.The control group was treated with levofloxacin,and the observation group was treated with levofloxacin combined with ceftazidime.The two groups were observed for improvement,recurrence,bacterial clearance and adverse events.Results:In the observation group,the time of fever,urinary urgency and pain relief time,and urinary bacteria negative time were respectively(2.02±0.45)d,(4.61±1.16)d,(2.57±0.43)d,all lower than the control group,P<0.05;The probability of recurrence and bacterial clearance were 1.59%and 98.41%,respectively.Adverse events rates in observation group(7.94%)showed no significant difference compared with control group,P>0.05.Conclusion:Levofloxacin combined with ceftidine in the treatment of urinary tract infection is effective,which can significantly control the disease and reduce the risk of recurrence.