脊髓损伤的代谢组学研究进展

Advance in Metabolomics of Spinal Cord Injury(review)

脊髓损伤常导致机体不同程度的感觉及运动功能障碍,造成永久残疾,且并发症多,难以治愈。代谢组学作为一种新发展的技术,通过分析个体应激后代谢物的变化,找出用于辅助诊断、治疗或判断预后的特异性生物标志物,能够在疾病早期为患者制定最佳的治疗及康复方案。目前已有相关研究在脊髓损伤的诊断、治疗和预后监测等方面取得一定成果,鉴别了一些具有潜在价值的生物标志物,但脊髓损伤后的病理生理机制尚不完全清楚,相关生物标志物也缺少临床试验的验证。

Spinal cord injury(SCI)often causes different degrees of sensory and motor dysfunction,resulting in permanent disability,with many complications and difficult to cure.Metabolomics,as a new developing technique,identifies specific biomarkers for diagnosis,treatment or prognosis judgement by analyzing the changes in the metabolites after individual stress,and can make the best treatment and rehabilitation program for the patients in the early stage of the disease.At present,some achievements have been made in the diagnosis,treatment and prognosis monitoring of spinal cord injury,and some potential biomarkers have been identified.However,the pathophysiology of spinal cord injury is not fully understood,and relevant biomarkers are also lacking in clinical trials.