替格瑞洛与氯吡格雷序贯治疗在STEMI急诊PCI患者中的应用

Sequential Therapy With Ticagrelor and Clopidogrel in Patients With STEMI in Emergency PCI

目的分析替格瑞洛与氯吡格雷序贯治疗急性ST段抬高型心肌梗死(STEMI)急诊经皮冠状动脉介入术(PCI)临床效果。方法选取急诊PCI治疗STEMI患者88例作为研究对象,将其分为观察组(替格瑞洛与氯吡格雷序贯治疗)和对照组(氯吡格雷),每组各44例。结果观察组术后2 h、24 h血小板聚集率降低比对照组明显,差异具有统计学意义(P<0.05);两组患者术后7 d血小板聚集率、出血事件发生率比较,差异无统计学意义(P>0.05)。结论STEMI患者急诊PCI治疗时应用替格瑞洛与氯吡格雷序贯治疗,效果显著。

Objective To analyze the clinical effects of sequential tegrlorol and clopidogrel in the treatment of acute ST-segment elevation myocardial infarction(STEMI)in emergency percutaneous coronary intervention(PCI).Methods 88 cases of patients with STEMI who were treated with emergency PCI were selected as the study objects and they were divided into the observation group(sequentially treated with ticagrelor and clopidogrel)and the control group(clopidogrel),44 cases in each group.Results The decrease of platelet aggregation at 2 h and 24 h in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in platelet aggregation rate and bleeding rate between the two groups at 7 days after operation(P>0.05).Conclusion Sequential treatment with ticagrelor and clopidogrel in STEMI patients undergoing emergency PCI has a significant effect.