局部晚期乳腺癌术后后程同步放化疗及序贯治疗的对比分析

Comparative Analysis of Postoperative Radiochemotherapy and Sequential Treatment in Patients With Local Advanced Breast Cancer

目的分析对比局部晚期乳腺癌术后后程同步放化疗及序贯治疗的临床疗效。方法选取2007年10月—2018年2月我院收治的500例局部晚期乳腺癌患者作为研究对象。按照抽签法,将其分为A组(n=250,术后予以同步放化疗)和B组(n=250,术后予以序贯治疗),对比两组治疗效果的差异。结果 A组开始放疗时间、放化疗全程治疗时间均短于B组组间对比,差异具有统计学意义(P<0.05);随访期间两组局部复发率、远处转移率进行比较,差异无统计学意义(P>0.05)。结论与序贯治疗方法相比,局部晚期乳腺癌术后后程同步放化疗可显著缩短治疗时间,更具可行性。

Objective To analyze the clinical efficacy of postoperative radiotherapy and chemotherapy combined with sequential therapy in the treatment of locally advanced breast cancer.Methods From October 2007 to February 2018,500 patients with locally advanced breast cancer were selected as the study subjects.They were divided into group A(n=250,postoperative concurrent radiotherapy and chemotherapy)and group B(n=250,postoperative sequential treatment).The difference of therapeutic effects between the two groups was compared.Results The time of starting radiation therapy and the whole course of radiotherapy and chemotherapy in group A were significantly shorter than those in group B,the difference was statistically significant(P<0.05).The rates of local recurrence and distant metastasis in the two groups were compared during the follow-up period.There was no significant difference between group B and no statistical significance(P>0.05).Conclusion Compared with sequential therapy,postoperative concurrent radiotherapy and chemotherapy for locally advanced breast cancer can significantly shorten the treatment time and is more feasible.