不同年龄段的射血分数保留心力衰竭患者的临床特征

Clinical features of heart failure with preserved ejection fraction in patients with different age

目的分析≥65岁与<65岁的射血分数保留心力衰竭(heart failure with preserved ejection fraction,HFpEF)患者的临床特征。方法将274例HFpEF住院患者按年龄分为≥65岁组(228例)和<65岁组(46例),比较两组的临床资料,分析其相关因素。结果≥65岁HFpEF患者更可能是女性并且合并有原发性高血压(高血压)、冠状动脉粥样硬化性心脏病(冠心病)病史;<65岁HFpEF患者更可能是男性、肥胖人群并且具有吸烟史、糖尿病、肾功能不全、高脂血症病史。Logistic多因素回归分析显示,高尿酸血症和同型半胱氨酸与≥65岁HFpEF患者呈正相关。结论不同年龄组的HFpEF患者临床特征存在诸多差异,可能需要采取不同的防治方案。

Objectives To analyze the clinical features of heart failure with preserved ejection fraction(HFpEF)in patients of≥65 years old and<65 years old.Methods A total of 274 patients hospitalized with confirmed HFpEF were included in this study(228 were≥65 years old and 46 were<65 years old).Clinical features and related factors affecting the two types of HFpEF patients were compared between the two groups.Results≥65 years old patients were more likely to be female,and to had histories of hypertension and coronary heart disease than<65 years old patients with HFpEF.<65 years old patients with HFpEF were more likely to be male,obese and to had histories of smoking,diabetes,renal insufficiency and hyperlipidemia than≥65 years old patients with HFpEF.Logistic regression analysis showed that hyperuricemia and homocysteine significantly correlated with≥65 years old patients with HFpEF.Conclusions There are many differences in the clinical features of patients with HFpEF in different age,and different preventive and therapeutic measures might be needed.