丹酚酸B对骨髓间充质干细胞分化方向的影响

Effect of salvianolic acid B on differentiation direction of bone marrow mesenchymal stem cells

背景:随着组织工程学的不断发展,骨髓间充质干细胞的多向分化潜能为多种疾病的治疗带来了新的希望。近年来的研究发现,丹参的主要有效成分丹酚酸B具有多种药理活性,可以影响骨髓间充质干细胞的定向分化。目的:综述丹酚酸B对骨髓间充质干细胞分化方向的影响及具体机制。方法:分别以"丹酚酸B、骨髓间充质干细胞/骨髓基质干细胞、分化""Salvianolic acid B,differentiation/osteogenic/adipogenesis,mesenchymal stem cells"为检索词,由第一作者检索2000年1月至2017年9月在中国期刊全文数据库、PubM ed数据库及万方数据库发表的相关文章,其中中文102篇,英文136篇,最终选取具有代表性的49篇文献进行归纳总结。结果与结论:目前发现,丹酚酸B可以促进骨髓间充质干细胞成骨分化、成神经分化、成心肌细胞分化,抑制骨髓间充质干细胞成脂分化。丹酚酸B是否可以促进骨髓间充质干细胞向其他方向分化及在促进不同分化方向上的有效浓度仍有待于进一步研究。

BACKGROUND:With the development of tissue engineering,the multi-directional differentiation potential of bone marrow mesenchymal stem cells has brought a new hope for the treatment of many diseases.Salvianolic acid B,as an effective component of Salvia miltiorrhiza Bunge,has many pharmacological activities influencing the directional differentiation of bone marrow mesenchymal stem cells.OBJECTIVE:To summarize the effect of salvianolic acid B on the differentiation of bone marrow mesenchymal stem cells and to explore the underlying mechanisms.METHODS:The first author searched the CNKI,WanFang and PubMed databases using the keywords of“salvianolic acid B,directional differentiation,mesenchymal stem cells”in Chinese and English,respectively,to retrieve relevant articles published from January 2000 to September 2017.One hundred and two Chinese articles and 136 English articles were initially retrieved.Repetitive articles or those with no originality were eliminated.Finally 49 articles were included in the result analysis.RESULTS AND CONCLUSION:It has been found that salvianolic acid B can promote the osteogenic,neuronal and myocardial differentiation of bone marrow mesenchymal stem cells,but inhibit the adipogenic differentiation of the cells.Further investigations are required on whether salvianolic acid B can promote the mutli-directional differentiation of bone marrow mesenchymal stem cells and its effective concentrations.