糖皮质激素受体在白癜风患者外周血单核细胞中的表达分析

Expression of glucocorticoid receptor in peripheral blood mononuclear cells of vitiligo patients

目的分析糖皮质激素受体在白癜风患者外周血单核细胞中的表达情况。方法选择2016年1月~2017年1我院收治的100例白癜风患者为研究对象,另取同期接受体检的健康者100例为对照组。对外周血单核细胞的GCR表达水平加以检测,分析结果。结果节段型白癜风患者GCR的表达情况和正常对照组相似,P>0.05。与上述两者相比,寻常型白癜风患者的GCR的表达情况明显下降,P<0.05。寻常型白癜风患者外周单核细胞GCR表达和病程呈现负相关,病程越长,GCR表达越低,R=-0.22,P<0.05.(P=0.021)两者之间存在统计学差异,P<0.05.(P=0.012).节段性白癜风组患者上述两项指标无相关性。结论 hGR β和hGR α mRA可能在白癜风患者疾病发展中起到了一定作用。糖皮质激素受体表达量过低,会对糖皮质激素治疗效果造成影响,导致炎症反应无法得到及时控制,引发疾病迁延不愈。

Objective To analyze expression of glucocorticoid receptor(GCR)in peripheral blood mononuclear cells of vitiligo patients..Methods 100 cases of vitiligo from January 2016 to 2017 in our hospital were selected as the subjects,and 100 healthy persons who received physical examination in the same period as the control group.The expression level of GCR in peripheral blood mononuclear cells was detected,and the results were analyzed.Results The GCR expression in segmental vitiligo was similar to that in normal group,P>0.05.Comparing with above two groups,GCR expression was significantly decreased in normal vitiligo patients,P<0.05,The expression of GCR in peripheral blood mononuclear cells was negatively correlated with the course of disease in patients with vitiligo.The longer the course of disease,the lower the expression of GCR,R=-0.22,P<0.05.(P=0.021),the difference was significant,P<0.05(P=0.012).There was no correlation between the above two indexes in segmental vitiligo group.Conclusion hGRβand hGRαmRA might play a role in vitiligo patients during disease development.The lower GCR expression can affect the effect of glucocorticoid treatment,which leads to the lack of timely control of the inflammatory reaction and the cause of disease deferred.