益生菌对高血压影响的研究进展

Recent Advances in Understanding the Potential Impact of Probiotics on Hypertension

肠道菌群在代谢综合征、心血管疾病和结直肠癌等疾病中的研究已经成为焦点,但是肠道微生物与这些疾病的因果关系以及相应的致病机制尚不清楚。通过分析肠道菌群结构、组成以及代谢活动的变化对高血压的影响,能够揭示肠道以及肠道微生物的活动与高血压之间的相关性。益生菌是对机体健康产生有益作用的活的微生物,可以调节肠道微生态的平衡以及肠道微生物的代谢活动,从而对高血压的调节产生影响,进而为以肠道微生物为靶点干预治疗高血压疾病提供理论参考,同时也为疾病的干预治疗提供新的途径和方法。

Emerging evidence suggests that metabolic syndrome,cardiovascular diseases and colorectal cancer are closely associated with the gut microbiota,and the role of these bacteria in the treatment of these diseases has gained considerable research attention,but the pathogenesis and the causal relationship between the gut microbiota and these diseases have not been elucidated to date.The objective of this review is to analyze the changes in structure and species composition as well as metabolic activities of the gut microbiota that can affect the regulation of blood pressure.The association between the gut microbiota and hypertension is discussed in this article.Probiotics are live organisms that are benefit for health and helpful to regulate the balance of the gut ecology.This regulation plays a key role in blood pressure control.In addition,the effect of probiotics on the activity of the gut microbiota is also investigated.Finally,the potential application of gut microbiome as a target in the development of novel therapy for hypertension will be an important research area.