摘要
目的:探讨中药金银花提取物的降糖作用。方法:从四种金银花地方品种忍冬(LMPB)、山银花(LCPB)、红腺忍冬(LHPB)、毛花柱忍冬(LFPB)的花蕾中提取多糖组分,采用链脲佐菌素(STZ)诱导制造Ⅱ型糖尿病大鼠模型,设正常对照组(NC),模型对照组(STZ),金银花阳性药组(STZ+LMPB;STZ+LCPB;STZ+LHPB;STZ+LFPB)。阳性药组每日分别口服该四种提取物800 mg/kg,共42天。观察各组大鼠血糖和胰岛素水平及血糖、血脂及代谢酶活性指标。结果:统计分析结果表明:与对照组及模型组比较,阳性药组食物和水摄入量减少(P<0.05,P<0.01),血糖和胰岛素水平降低(P<0.01,P<0.05)。同时总胆固醇(TC,45.8%~51.0%,P<0.05),总甘油三酯(TG,50.6%~53.8%,P<0.01),低密度脂蛋白胆固醇(LDL-C,71.2%~76.3%,P<0.01)和极低密度脂蛋白胆固醇(VLDL-C,45.2%~50.0%,P<0.01),高密度脂蛋白胆固醇显著升高(HDL-C,21.6%~24.3%,P<0.05)。同时阳性药物组血清ALT、AST和GGT显著降低(P<0.05),肝脏CAT、SOD和GSH显著增加(P<0.05)。结论:上述结果表明,四种中药金银花提取物多糖组分具有显著的降血糖作用,可作为Ⅱ型糖尿病功能性食品的有效成分。
Objective:To investigate the hypoglycemic effect of extract of Jinyinghua(金银花).Methods:Polysaccharide fractions were extracted from the buds of four Jinyinghua,LMPB,LPCB,LHPB and LFPB.And streptozotocin(STZ)was applied to establish type II diabetic rat model,set the normal control group(NC),model group(STZ),honeysuckle positive drug group(STZ+LMPB,STZ+LCPB,STZ+LHPB,STZ+LFPB).The positive drug group was given the four extracts 800 mg/kg daily,for 42 days.The blood glucose and insulin levels,and the indexes of blood glucose,blood lipids,and metabolic enzyme activity were observed in each group.Results:Statistical analysis showed that compared with the control and model groups,food and water intake in the positive drug group were decreased(P<0.05,P<0.01),and blood glucose and insulin levels were decreased(P<0.01,P<0.05).At the same time,total cholesterol(TC,45.8%~51.0%,P<0.05),total triglycerides(TG,50.6%~53.8%,P<0.01),low density lipoprotein cholesterol(LDL-C,71.2%~76.3%,P<0.01)and very low-density lipoprotein cholesterol(VLDL-C,45.2%~50.0%,P<0.01),high-density lipoprotein cholesterol were significantly increased(HDL-C,21.6%~24.3%,P<0.05).Serum ALT,AST,and GGT in the positive drug group were significantly lower(P<0.05),and liver CAT,SOD,and GSH were significantly increased(P<0.05).Conclusion:The above results indicate that the polysaccharide components of the four extracts of Jinyinghua have significant hypoglycemic effects,and can be used as effective ingredients of type II diabetes functional foods.
出处
《中医临床研究》
2018年第19期4-7,共4页
Clinical Journal Of Chinese Medicine
关键词
金银花
多糖
Ⅱ型糖尿病
降糖
Jinyinghua
Amylose
Type II diabetes
Gibenclamide