GYF结构域蛋白特性及其生物学功能研究进展

Study Progress of the Characterization and Biological Function of GYF Domain Protein

甘氨酸-络氨酸-苯丙氨酸(glycine-tyrosine-phenylalanine,GYF)结构域是一种小型的、能识别富脯氨酸序列(proline rich sequences,PRS)的保守、多功能接合结构域,GYF结构域蛋白在蛋白蛋白相互作用、翻译起始、mRNA剪接、监管与翻译抑制、泛素连接、信号转导、免疫蛋白酶调控等方面起重要作用。本文从结构域特性、与靶蛋白的相互作用及其功能等方面综述GYF结构域蛋白的研究进展。

GYF domains are small,conservative,versatile adaptor domains that recognize proline-rich sequences(PRS).GYF domain proteins play important roles in protein protein interaction,translational initiation,mRNA splicing,surveillance and translation suppression,ubiquitin ligation,signal transduction and immune protease regulation,et al.The study progress of GYF domain protein on aspects of domain characters,interaction with target proteins as well as its function were reviewed in the paper.