牙周梭杆菌血流感染一例报告并文献复习

Bloodstream infection caused by Fusobacterium periodonticum: one case report and literature review

目的了解牙周梭杆菌血流感染的检测方法及临床特征。方法对1例牙周梭杆菌菌血症患者的临床表现、实验室检查结果进行分析,并结合相关文献复习牙周梭杆菌菌血症的检测方法。结果该例患者为中性粒细胞缺乏合并发热,血培养检测出革兰阴性杆菌,该菌经基因测序鉴定为牙周梭杆菌,患者使用甲硝唑联合美罗培南抗感染治疗后康复出院。通过文献复习发现牙周梭杆菌引起的血流感染在国内外未见相关文献报道,在牙周梭杆菌菌株鉴定上,9篇文献中5篇通过DNA-DNA杂交鉴定,3篇通过PCR鉴定,2篇通过16S rRNA序列分析鉴定。结论牙周梭杆菌在血液病等免疫力低下的患者中可引起血流感染,常规方法鉴定困难,可以通过PCR和基因测序等方法对牙周梭杆菌引起的败血症进行鉴定。

Objective To understand detection method and clinical characteristics of bloodstream infection caused by Fusobacterium periodonticum(FP).Methods Clinical manifestation and laboratory examination results of one case of bacteremia caused by FP was analyzed,detection methods of FP were reviewed with relevant literatures.Results This patient has neutropenia with fever,gram-negative bacillus was isolated from blood culture,the strain was identified as FP by gene sequencing,patient was discharged from hospital after received metronidazole combined meropenem for anti-infection treatment.Through literature review,it is found that there was no reported literature on bloodstream infection caused by FP.Identification of FP in 9 literatures showed that FP in 5 literatures were identified by DND-DND hybridization,3 by PCR method,and 2 by 16S rRNA gene sequence analysis.Conclusion FP can cause bloodstream infection in patient with low immunity,it is difficult to be identified by conventional method,PCR and gene sequencing can be used for identification of septicemia caused by FP.