芽孢杆菌合成环脂肽的研究进展

ADVANCE IN STUDY ON CYCLIC LIPOPEPTIDES PRODUCED BY BACILLUS

芽孢杆菌是一类耐热、耐酸碱的细菌,能产生多种抗菌活性物质。芽孢杆菌合成的环脂肽由于结构的多样性和丰富的生物学功能的优越性而备受关注。环脂肽主要由一个肽环和脂肪酸链组成,是一类具有亲水和亲油特性的化合物,具有抗细菌、抗真菌、抗炎、抗肿瘤和抗病毒等生物学功能,故在生物防治、环境保护和医药治疗等方面具有潜在的应用价值。从环脂肽的不同类型结构特征、多种生物学功能、生物合成机制、分离纯化过程、结构鉴定方法与新型环脂肽筛选技术这些方面综述其研究进展。讨论与展望了环脂肽研究的不足、解决途径及未来发展前景。旨在能够快速地了解到环脂肽的相关信息及研究状况,同时也为新型环脂肽的开发和利用提供理论参考。

Bacillus is a kind of Gram-positive bacteria that can withstand heat,acid and alkali,and produce many kinds of antimicrobial substances.The cyclic lipopeptide from Bacillus has attracted much attention due to its structural diversity and many biological functions.Cyclic lipopeptide is composed of a peptide ring and fatty acid chain.It has hydrophilic and lipophilic property.Cyclic lipopeptide has diverse function such as antibacterial,antifungal,anti-inflammatory,antitumor and antiviral and therefore it has potential application value in biological control,environmental protection and medical treatment.The research progresses of cyclic lipopeptides in structural features of different types,many biological functions,biosynthesis mechanisms,separation and purification processes,structural identification methods and screening techniques for new cyclic were reviewed in this paper.Finally,the shortcomings,solutions and future development of cyclic lipopeptides were discussed and prospected.The aim is to help more researchers to quickly understand the information of cyclic lipopeptide.At the same time,it also provides a theoretical reference for the development and utilization of the new cyclic lipopeptide.Key word: