蜈蚣草化学成分及抑制乙酰胆碱酯酶生物活性研究

Study on the Constituents and Acetylcholinesterase Inhibitory Activity of Pteris vittata

采用多种分离分析手段对蜈蚣草(Pteris vittata)乙醇提取物进行系统的化学成分和乙酰胆碱酯酶抑制活性研究,应用现代波谱技术鉴定了其中的6个化学成分,分别是芹菜素(1)、芹菜素-7-O-β-D-葡萄糖苷(2)、木犀草素(3)、木犀草素-7-O-β-D-葡萄糖(4)、山柰素-3-O-β-D-葡萄糖苷(5)、β-谷甾醇(6),所有化合物均系首次从该种中获得。化合物5具有一定抑制乙酰胆碱酯酶活性。

The chemical constitutes of the EtOH extract of Pteris vittata from Jiangxi Province were studied.Severn compounds were isolated by repeated gel column chromatography.On the basis of spectral data,their structures were characterized as apigenin(1),apigenin-7-O-β-D-glucopyranoside(2),luteolin(3),luteolin-7-O-β-D-glucopyranoside(4),kaempferol-3-O-β-D-glucopyranoside(5),β-sitosterol(6).All Compounds were isolated from this species for the first time.Compound 5 showed a certain acetylcholinesterase inhibitory activity.