喹啉-2-甲醛类希夫碱铜配合物的合成及其生物活性

Synthesis and bio-activity of copper(ii) complex of schiff-base derived from quinoline-2-carboxaldehyde

合成一种新的喹啉-2-甲醛缩组胺希夫碱铜(II)配合物[Cu(Quin-Hist)Cl2],利用元素分析和红外光谱对其进行表征,通过X线单晶衍射确定其晶体结构。研究结果表明:该晶体属于单斜晶体,P21/n空间群,晶胞参数为a=0.858 90(7)nm,b=1.282 38(10)nm,c=1.459 76(12)nm,β=99.346 0(10)°;配合物为畸变的三角双锥空间构型;该铜(II)配合物能与小牛胸腺DNA(CT-DNA)之间通过沟槽结合的方式相互作用;此外,铜(II)配合物对MCF-7人乳腺癌细胞系、A-549人非小细胞肺癌细胞系和SKOV-3人卵巢癌细胞系均有较强的体外细胞毒活性,且与顺铂相比,铜(II)配合物对MCF-7细胞系具有更强的体外细胞毒活性。

A novel copper(II)complex,i.e.[Cu(Quin-Hist)Cl2](Quin-Hist=2-(4-imidazolyl)ethylimino-quinoline),was prepared and structurally characterized by elemental analysis and IR spectra.The results show that the complex crystallized belongs to monoclinic space group P21/n with a=0.858 90(7)nm,b=1.282 38(10)nm,c=1.459 76(12)nm,β=99.346 00(10)°.The copper(II)ion is situated in a trigonal bipyramid geometry.There is apparent interaction between the copper(II)complex and calf thymus DNA(CT-DNA)via a groove binding mode.Moreover,the copper(II)complex exhibits in vitro cytotoxicity against MCF-7,A549 and SKOV-3 cell lines.Especially,the copper(II)complex shows higher growth inhibitory rates than cisplatin against MCF-7 cell line.