改良川岛瘙痒严重度评价方法与视觉模拟评分法的相关性

Correlation between Ameliorated Kawashima Itch Scale and Visual Analogue Scale

目的以患有瘙痒症的成年维持性血液透析患者为对象,初步验证改良川岛(谢-川岛)瘙痒严重度评价方法的临床适用性。方法对川岛瘙痒严重度评价方法进行改良,建立谢-川岛瘙痒严重度评价方法。患者根据谢-川岛瘙痒严重度评价方法以及视觉模拟评分法(VAS),每日自我评价日间及夜间的瘙痒状态,连续记录两周。采用患者在第2周的记录,分析谢-川岛瘙痒严重度评价方法与VAS之间的相关性。结果共入组134例病例,其中128例有效病例数据纳入分析。谢-川岛瘙痒严重度评价方法 (患者评价)与VAS呈正相关(基于日间瘙痒状态的Spearman秩相关系数为0.832,95%可信区间为0.810~0.851,P<0.01;基于夜间瘙痒状态的Spearman秩相关系数为0.848,95%可信区间为0.828~0.865,P<0.01);此外,基于年龄或性别的分层分析结果显示各组间呈现相似的相关性。结论谢-川岛瘙痒严重度评价方法在血液透析患者中与VAS呈现出良好的相关性,且不受患者的年龄或性别影响,可应用于临床诊疗或研究时瘙痒严重度的测评或补充测评工具。

Objective To preliminarily validate the clinical usability of the ameliorated Kawashima Itch Scale(Xie-Kawashima Itch Scale)among adult pruritic patients on maintenance hemodialysis.Methods Xie-Kawashima Itch Scale was developed on the basis of Kawashima Itch Scale.Patients were asked to record their pruritus condition according to Xie-Kawashima Itch Scale or visual analogue scale(VAS)during daytime and night for two weeks.The record at the second week was used for analyzing the correlation between Xie-Kawashima Itch Scale and VAS.Results Totally 134 patients were enrolled in this study,among whom 128 entered the final analysis.Xie-Kawashima Itch Scale was positively correlated with VAS(r s=0.832,95%CI=0.810-0.851,P<0.01 for daytime record;and r s=0.848,95%CI=0.828-0.865,P<0.01 for night record).Subgroup analysis also showed similar correlations between different age groups and among different gender groups.Conclusions Xie-Kawashima Itch Scale has good correlation with VAS in patients on hemodialysis,without being affected by age or gender.Thus,it can be a useful tool for the assessment of pruritus in clinical practice and research.