北碚地区中老年人群骨健康状态的三维定量CT评价

Three-dimensional Quantitative CT in Evaluation of Bone Health in Middle-aged and Elderly Population in Beibei Area

目的探讨北碚地区不同性别中老年人骨密度(BMD)的变化规律,以及该地区低骨量的高发年龄与骨质疏松症(OP)的高发病率。资料与方法采用三维定量CT(3D-QCT)对常住北碚地区的1012例40~80岁中老年人进行腰椎BMD测量,以5岁为一个年龄组,比较不同性别中老年人各年龄段正常骨量、低骨量和OP的发生率。结果北碚地区不同性别中老年人的BMD变化与年龄增长均呈负相关(r=-0.758、-0.715,P<0.05),BMD随年龄增长而降低,60~80岁组女性BMD明显低于同年龄组男性,差异有统计学意义(P<0.05)。男、女性骨量减低分别在50~64岁(发生率为46.67%~56.52%)和50~59岁(发生率为45.45%~55.77%)。男性65岁以后、女性60岁以后OP的发生率明显升高。结论不同性别中老年人BMD的变化规律相似,OP高发病率紧随低骨量的高发年龄之后。因此,提前关注低骨量人群,有助于预防OP。

Purpose To explore the changes of bone mineral density(BMD)in middle-aged and elderly people in Beibei,as well as the vulnerable age of low bone mass and high incidence of osteoporosis(OP).Materials and Methods Three-dimensional quantitative CT(3D-QCT)was used to measure the BMD of the lumbar spine of 1,012 middle-aged and elderly people(aged from 40 to 80)in Beibei area.The age groups were established with 5 years as the interval,the incidence of normal bone mass,low bone mass and OP between these groups were compared.Results BMD changes and age growth were negatively correlated for both males and females(r=-0.758 and-0.715,P<0.05).BMD decreased with age,and BMD of women aged 60-80 was significantly lower than that of men in the same age group,with statistically significant difference(P<0.05).The vulnerable age bracket of bone mass reduction in men and women was respectively 50-64 years old(incidence of 46.67%-56.52%)and 50-59 years old(incidence of 45.45%-55.77%).The incidence of OP increased significantly after the age of 65 for men and 60 for women.Conclusion The changes of BMD are similar in the elderly with different genders,and the high incidence of OP closely follows the high incidence of low bone mass.Therefore,paying attention to low bone mass in advance can help prevent OP.