基于熵指数法监测管理对重症机械通气患者镇静药物用量的影响

Influence of Entropy Index Method Based Monitoring Management on Sedative Drug Dosage for Patients with Severe Mechanical Ventilation

目的探讨基于熵指数法的监测管理对重症机械通气患者镇静药物用量的影响。方法重症监护病房(ICU)重症机械通气患者61例,采用随机数字表法分为治疗组(n=31)与对照组(n=30),全部患者机械通气期间采用右美托咪定镇静,对照组实施基于Ramsay镇静评分系统的监测管理,治疗组实施基于熵指数法的监测管理。结果治疗组和对照组镇静药物用量分别为(13.25±3.21),(43.15±5.61)μg·h-1,停药后苏醒时间分别为(3.26±1.54),(9.06±1.87)min,机械通气时间分别为(4.56±1.63),(6.59±2.08)d(均P<0.01)。两组心率、平均动脉压均差异无统计学意义(P>0.05),均未出现非计划拔管事件与药物过敏等不良反应。结论基于熵指数法的监测管理可减少重症机械通气患者镇静药物用量,促进机体恢复,安全,有效。

Objective To study the influence of entropy index method based monitoring management on sedative drug dosage for patients with severe mechanical ventilation.Methods Totally,61 cases patients with severe mechanical ventilation from intensive care unit(ICU)were selected,the patients were divided into treatment group(n=31)and control group(n=30)by using the random number table method.All the patients were sedated with dexmedetomidine during mechanical ventilation.The control group were given Ramsay sedation score system based monitoring management,and the treatment group were given entropy index method based monitoring management.Results The sedative drug dosage of treatment group and control group were(13.25±3.21),(43.15±5.61)μg·h-1,the withdrawal awakening time were(3.26±1.54),(9.06±1.87)min,the mechanical ventilation time were(4.56±1.63),(6.59±2.08)d(all P<0.01).Heart rate(HR)and mean arterial pressure(MAP)level between the two group were not statistically significantly different(P>0.05).The two groups did not have unplanned extubation events and adverse reactions such as drug allergy.Conclusion Entropy index method based monitoring management can reduce sedative drug dosage for patients with severe mechanical ventilation,promote body recovery.It is effective and safe.