CAG重复长度与脊髓小脑性共济失调3型发病年龄相关性的Meta分析

Assiocation between CAG repeat length and age at onset of spinocerebellar ataxia type 3: A Meta-Analysis

目的采用Meta分析的方法,探讨CAG重复长度与脊髓小脑性共济失调3型发病年龄的相关性。方法收集关于CAG重复长度与脊髓小脑性共济失调3型发病年龄相关性的文献,采用R软件进行Meta分析。结果本次Meta分析共纳入12篇文献。总样本量为411名。Meta分析结果显示CAG重复长度与脊髓小脑性共济失调3型发病年龄合并相关系数及其95%CI-0. 9952(-1. 10;-0. 90)。亚组分析显示,CAG重复长度与SCA3发病年龄随年份的增加,相关性随之减小。随着样本量的增加,测出的相关系数值降低。种族不同,测出的相关系数有差异。对结果评估分析发现,种族能解释异质性的来源,本次Meta分析不存在发表偏倚。结论 (1)CAG重复长度与SCA3发病年龄存在强烈负相关,即CAG重复长度越长,SCA3发病年龄越小;(2) CAG重复长度占SCA3发病年龄差异的40. 6%,种族差异对SCA3发病年龄存在影响。

Objective To explore the association of CAG repeat length and age at onset of spinocerebellar ataxia type 3 by meta-nanlysis.Methods Collect literatures on the correlation between CAG repeat length and age at onset of spinocerebellar ataxia type 3.All the meta analysis in this study was carried out by R sofhtwore.Results A total of twelve studys were included in the meta analysis.The total sample amounts were 411 subjects.The results of Meta-analyses showed that merge correlation coefficient of CAG repeat length and age at onset of spinocerebellar ataxia type 3,and 95%cofidence interval(CI)were-0.9952(-1.10;-0.90).In the subgroup analysis,we found that the merge correlation coefficient of CAG repeat length and age at onset of spinocerebellar ataxia type 3 were reduced with the samples amounts increase,which of with the increase of years,the merge correlation coefficient decreased,the correlation coefficient mearsured by ethnicity was different.Moreover,we detect ethnicity could explain the source of heterogeneous,and there is no publication bias in the meta analysis.Conclusions (1)There is a strong negative correlation between the CAG repeat length and the age at onset of spinocerebellar ataxia type 3,the longer CAG repeat length,the younger the age at onset of the spinocereal ataxia type 3.(2)The repeat length of CAG accounted for 40.6%of the age at onset of the spinocereal ataxia type 3.Racial differences has an effect on the age at onset of the spinocereal ataxia type 3.