阿司匹林治疗早期复发性流产对子宫血流动力学的影响分析

Analysis of the effect of aspirin in the treatment of early recurrent abortion on uterine hemodynamics

目的研究阿司匹林治疗早期复发性流产对子宫血流动力学的影响。方法在本院妇产科2016年1月~2018年1月所收治的早期复发性流产患者中,随机选取80例作为研究对象即观察组进行研究,另选取80例无反复流产的研究对象作为对照组进行研究。所有检查对象取仰卧位,在排卵后6~8后(黄体期)进行彩超检查。观察组患者均给予阿司匹林治疗,在服药前与服药3个月后,均进行阴道彩超检查。记录子宫内膜的厚度,以及内膜血流、子宫动脉的参数,分析其对子宫血流动力学的影响。结果在阿司匹林服用前,于黄体中期进行超声检测,其中观察组患者子宫内膜的厚度明显低于对照组(P=0.0011);内膜血流中的PI、子宫动脉的m PI、m RI、m S/D均明显高于对照组,两组比较差异有统计学意义(P<0.05);观察组内膜血流中的RI、S/D稍稍高于对照组,差异无统计学意义。观察组患者在经小剂量的阿司匹林治疗后,在黄体中期经超声测量内膜血流与子宫动脉血流的各项参数,均比服药前低,且差异有统计学意义(P<0.05);子宫内膜的厚度在服药后比服药前稍厚,且差异有统计学意义(P<0.05)。结论阿司匹林可以改善早期复发性流产患者的血流动力学指标,提高妊娠成功率,且疗效安全可靠,值得在临床上进行推广应用。

Objective To investigate the effect of aspirin in the treatment of uterine hemodynamics in the treatment of early recurrent abortion.Methods Of the early recurrent abortion patients in the Department of Obstetrics and Gynecology of our hospital in January 2016to January 2018,80 cases were selected as the study object,namely the observation group,and 80 cases of no recurrent abortion were selected as the control group.All the subjects were taken in the supine position,and the color Doppler ultrasound examination was performed at 6-8d(luteal phase)after ovulation.The patients in the observation group were treated with aspirin.After taking the medicine and taking the medicine for three months,all the patients were examined by vaginal color Doppler ultrasound.The thickness of the endometrium,the blood flow of the endometrium and the parameters of the uterine artery were recorded,and the effect of the endometrium on the hemodynamics of the uterus was analyzed.Results In taking aspirin before ultrasonic testing in the mid luteal phase,the observation group of patients with endometrial thickness was significantly lower than the control group(P=0.001 1);endometrial blood flow in the PI,mPI,mRI of uterine artery and mS/D were significantly higher than the control group,the difference between the two groups was statistically significant(P<0.05);observation group the RI and S/D in endometrial blood flow is slightly higher than that of the control group,the difference was not statistically significant.The patients in the observation group after treatment with aspirin in small doses,the parameters of endometrial blood flow and uterine artery blood flow in the middle luteal phase were all lower than those before administration,and the difference was statistically significant(P<0.05);the thickness of the endometrium after taking the medication than before slightly thick,and the difference was statistically significant(P<0.05).Conclusion Aspirin can improve hemodynamic parameters in early recurrent spontaneous abortion,improve pregnancy success rate,and the effect is safe and reliable.It is worthy of clinical application.